Results 81 to 90 of about 9,088 (236)
Teaching in Lifelong Learning: A Journal to Inform and Improve Practice, 2011 This short article explores whether using a mentoring model supports our Subject Specialist Mentors (SSMs) with their role of mentoring trainees on Initial Teacher Training (ITT) courses. Although there are many mentoring models to choose from, our model
Bailey, Wayne, Schoch, Judith
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Partnerships in a global dimensions specialism on a BEd primary programme
, 2011 This book chapter is not available through ChesterRep. It can be accessed at http://www.lsbu.ac.uk/ccci/documents/tony%20pickford%20Partnerships%20in%20a%20Global%20Dimensions%20specialism%20on%20a%20B.Ed%20primary%20programme.pdfThis book chapter ...
Pickford, Anthony
core +2 more sources
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Viewpoint: A Familiar Frontier: British Defence Strategy and Spacepower
Air and Space Power Review, 2019 Spacepower’s time has come. In 2018 the political, economic, and military uses of outer space – spacepower – enjoyed a level of publicity and policy attention like never before on both sides of the Atlantic.
Bleddyn Bowen
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Tendencias Pedagógicas, 2015 This paper explain the objectives and some outputs of European Agency for Development in Special Needs Education project, Teacher Education for Inclusion (TE4I), that has explored how all teachers must be prepared via their initial training to be ...
Gerardo Echeita Sarrionandia
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