Results 121 to 130 of about 1,275,466 (358)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Recent scientific findings on the professional formation of technology teacher
Journal of Education, Health and Sport, 2016 The article reviews the latest scientific findings on the professional formation of technology teacher. It analyzes major approaches towards the models of major proficiency levelsand defines the notion of “professional identity of technology teacher”.
Ihor Hevko
doaj
PROCEDURAL POSITION OF A DOCTOR DURING EXAMINATION OF A CORPSE [PDF]
Legal BulletinThe article is devoted to the analysis of the procedural position of a doctor during the examination of a corpse in modern criminal proceedings. Its relevance is due to the normative and doctrinal uncertainty of the status of this participant in criminal
ZASHLYAPIN LEONID
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Clinical thinking as the important stage of future doctors preparation.
Journal of Education, Health and Sport, 2016 In the article the main stages of the formation of clinical thinking in future doctors from the point of view of industry standards "Educational and professional training program of a specialist" and "Educational and qualifying characteristics of a ...
Yu. V. Sukhin +2 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
In-reach specialist nursing teams for residential care homes : uptake of services, impact on care provision and cost-effectiveness [PDF]
, 2008 Background: A joint NHS-Local Authority initiative in England designed to provide a dedicated nursing and physiotherapy in-reach team (IRT) to four residential care homes has been evaluated.The IRT supported 131 residents and maintained 15 'virtual' beds
Nelson Sara +8 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Exploring competency-based medical education among specialist doctors in Malaysia [PDF]
, 2017 This research was done with the objective to explain the development process of medical specialist when they went through continuous learning process via the Continuing Professional Education (CPE) upon being recognized as a medical specialist.
Tukiman, Nur Fariza +1 more
core