Results 131 to 140 of about 1,275,466 (358)

Characteristic Features of Professional Study of Physical Education and Sports in the USA

Фізичне виховання, спорт і культура здоров’я у сучасному суспільстві, 2017
Actuality. Innovative processes in the field of physical culture and sports, understanding the value of health, recognition of high social importance of physical education, promotion of fitness, physical activities and sports, creating a positive public
Serhii Medynskyi
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The impact of the specialist schools programme on exam results

The Government and its agencies have seriously overestimated the impact of the specialist schools programme on educational attainment. The substantially higher exam scores achieved on average by schools with specialist status are due primarily to sample ...
Jim Taylor
core  

Primary care provider referral patterns and awareness of biologic therapy for uncontrolled asthma

Journal of Allergy and Clinical Immunology: Global
Background: Asthma is a chronic airway disease associated with substantial morbidity. Most patients with uncontrolled asthma in the United States are managed by primary care providers (PCPs) and not by asthma specialists who are frequently updated on ...
Juan Carlos Cardet, MD, MPH, Bijalben Patel, MD, Phuong Bradford, DNP, APRN, FNP-BC, Elisabeth Callen, PhD, PStat, Tarin L. Clay, BA, Brenda Flam, PhD, John Fowler, BS, Lucy Guerra, MD, MPH, Christina Hester, PhD, MPH, R. Meredith Plant, MD, Panida Sriaroon, MD, Krizia Trasmonte, DO, Dennis Ledford, MD   +12 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A tough nut to crack: performance measurement in specialist policing [PDF]

, 2012
  As police forces worldwide increase the number of specialist units within their organisational structures, they require innovative performance measurement frameworks to properly evaluate the effectiveness of these units within the broader ...
Charl Crous, Zhivan Alach
core  

ISSUES OF COMBINING FUNCTIONS OF A SPECIALIST AND AN EXPERT IN ONE PERSON IN THE SAME LEGAL CASE

Теория и практика судебной экспертизы, 2014
The author analyzes legal status of the specialist, gives the interpretation to the notionof «specialist». The work also pays attention to problem of combining the functions ofan expert specialist.
L. Morosov
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The Specialist Disability Accommodation Landscape in Queensland [Draft Report - April 2021]

, 2021
The introduction of the National Disability Insurance Scheme (NDIS) has significantly changed both the disability service and support sector, and disability housing landscape. Since the introduction of Specialist Disability Accommodation (SDA) funding to
Bitner, Grace, Gillett, Coral, Foster, Michele   +2 more
core