Results 131 to 140 of about 193,296 (299)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Drug specialist alleges inaction on drug abuse.

, 2012
A leading drug specialist has called for the urgent expansion of GP methadone treatment services in order to tackle unnecessary drug deaths, labelling “our deadly indifference” a national scandal.
Mudiwa, Lloyd
core  

Performance and cost of a Renal Cancer Specialist Multidisciplinary Team Meeting: Results from 1500 discussions [PDF]

, 2019
OBJECTIVES: To report on the performance and cost of a surgeon-led renal cancer specialist multidisciplinary team meeting at a high-volume centre. MATERIALS AND METHODS: Retrospective analysis of 1500 consecutive cases discussed from 2 September ...
Powles, Tom, Aitchison, Michael, Tran, Maxine GB, Specialist Centre for Kidney Cancer, Neves, Joana B, Cullen, David, Shepherd, Scott   +6 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population

Human Genomics
Background SLCO1B1 plays an important role in mediating hepatic clearance of many different drugs including statins, angiotensin-converting enzyme inhibitors, chemotherapeutic agents and antibiotics.
Ewa Goljan, Mohammed Abouelhoda, Asma Tahir, Mohamed ElKalioby, Brian Meyer, Dorota Monies   +5 more
doaj   +1 more source

LYSOZYME-INDUCED NEPHROPATHY IN CMML: A RARE BUT SIGNIFICANT COMPLICATION REQUIRING EARLY RECOGNITION AND INTERVENTION

Hematology, Transfusion and Cell Therapy
Background: CMML is a clonal hematopoietic disorder with features of myelodysplasia and myeloproliferation, characterized by monocytosis. Monocytes secrete lysozyme, a cationic protein filtered by the glomerulus and reabsorbed in proximal tubules. Excess
Alfadil Haroon, Mohamed Kindawi, Ahmed S Alotaibi, Ali Debsan Alahmari, Hazzaa Alzahrani, Mansour Alfayez, syed Osman Ahmed   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma

Orphanet Journal of Rare Diseases
Giant prolactinomas are defined as pituitary adenomas (PAs) ≥ 4 cm with plasma prolactin level > 1000 ng/ml with no other co-secretory component. The reasons for development of giant prolactinomas are not clear but genetics play an important pathogenic ...
Eman Albasri, Balgees Alghamdi, Avaniyapuram Kannan Murugan, Eyas Othman, Sarah Alotaibi, Mohammad Anas Dababo, Ahmed Alfares, Ali S. Alzahrani   +7 more
doaj   +1 more source

Correction to: "Remoteness from urban centre does not affect gastric cancer outcomes with established care pathway to specialist centre". [PDF]

Can J Surg, 2023
europepmc   +1 more source

Children with COVID-19 at a specialist centre: initial experience and outcome. [PDF]

Lancet Child Adolesc Health, 2020
Issitt RW, Booth J, Bryant WA, Spiridou A, Taylor AM, du Pré P, Ramnarayan P, Hartley J, Cortina-Borja M, Moshal K, Dunn H, Hemingway H, Sebire NJ.   +12 more
europepmc   +1 more source