Results 111 to 120 of about 176,394 (255)

A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma

Orphanet Journal of Rare Diseases
Giant prolactinomas are defined as pituitary adenomas (PAs) ≥ 4 cm with plasma prolactin level > 1000 ng/ml with no other co-secretory component. The reasons for development of giant prolactinomas are not clear but genetics play an important pathogenic ...
Eman Albasri, Balgees Alghamdi, Avaniyapuram Kannan Murugan, Eyas Othman, Sarah Alotaibi, Mohammad Anas Dababo, Ahmed Alfares, Ali S. Alzahrani   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population

Human Genomics
Background SLCO1B1 plays an important role in mediating hepatic clearance of many different drugs including statins, angiotensin-converting enzyme inhibitors, chemotherapeutic agents and antibiotics.
Ewa Goljan, Mohammed Abouelhoda, Asma Tahir, Mohamed ElKalioby, Brian Meyer, Dorota Monies   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Trabecular bone score (Tbs) and fracture risk prediction in Asian type 2s diabetic subject

Osteoporosis and Sarcopenia, 2017
S.S. Yeap, L.F. Lee, Feiza K, C.K.T. Hew, H.K. Lim, J. Lim, F.L. Hew   +6 more
doaj   +1 more source

Time taken from primary care referral to a specialist centre diagnosis of idiopathic pulmonary fibrosis: an opportunity to improve patient outcomes? [PDF]

ERJ Open Res, 2020
Brereton CJ, Wallis T, Casey M, Fox L, Pontopiddan K, Laws D, Graves J, Titmuss V, Kearney S, Evans S, Grove A, Hamid S, Richeldi L, O'Reilly KMA, Fletcher SV, Jones MG.   +15 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

CD44 and phosphorylated ERK1/2 coexpression predicts distant metastasis in colorectal cancer based on a study of 1137 Saudi patients

Scientific Reports
Cluster of differentiation 44 (CD44) is a transmembrane glycoprotein implicated in tumor progression and metastasis, while phosphorylated ERK1/2 (p-ERK1/2) plays central role in MAPK pathway-driven oncogenic signaling.
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Fouad Al-Dayel, Khawla S. Al-Kuraya   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

In utero transfer to specialist centres. [PDF]

Archives of Disease in Childhood, 1983
openaire   +2 more sources