Results 111 to 120 of about 193,296 (299)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The impact of the specialist schools programme on exam results
The Government and its agencies have seriously overestimated the impact of the specialist schools programme on educational attainment. The substantially higher exam scores achieved on average by schools with specialist status are due primarily to sample ...
Jim Taylor
core
, 2007 Established in 1987, the Wolfson Centre has been a focus for materials research in Brunel University. Since its inception, the research in the Centre has been based on the development of extrusion and injection-moulding technologies relating to polymer ...
Tarverdi, K
core
Specialist Workers for Children and Young People Outcomes Evaluation – Final Report
The NSW Department of Communities and Justice (DCJ) commissioned a research team from the Social Policy Research Centre (SPRC) at UNSW Sydney to undertake an outcomes evaluation of Specialist Workers for Children and Young People (SWCYP) affected by ...
Cortis, Natasha ; https://orcid.org/ +4 more
core +1 more source
, 2012 AIM: To identify factors significant in influencing LOS following primary TKA in a UK specialist arthroplasty centre. METHOD: We retrospectively reviewed factors affecting LOS of 514 patients who underwent primary TKA in a single specialist arthroplasty ...
Jonas, Sam C +4 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Impact of SARS-CoV-2 (COVID-19) pandemic on patients with lysosomal storage disorders and restoration of services: experience from a specialist centre. [PDF]
Intern Med J, 2021 Ramaswami U +6 more
europepmc +1 more source
This paper estimates the impact of the Specialist Schools initiative and the Excellence in Cities programme on the attainment of secondary school pupils in England. The focus is on their relative impact across gender and ethnic groups.
G Migali, Jim Taylor, S Bradley
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source