Results 101 to 110 of about 193,296 (299)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Remoteness from urban centre does not affect gastric cancer outcomes with established care pathway to specialist centre. [PDF]

Can J Surg, 2023
Kammili A, Morency D, Cools-Lartigue J, Ferri LE, Mueller CL.   +4 more
europepmc   +1 more source

Civilian popliteal artery injuries : a ten year audit in an urban trauma centre

, 2011
The aim of this study is to identify factors associated with limb loss in patients with popliteal artery injuries. Retrospective chart review of a prospectively collected data base of all patients with popliteal artery injuries presenting to the Groote ...
Banderker, Mohammed Asif
core  

Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis.

, 2012
BACKGROUND: The PACE trial compared the effectiveness of adding adaptive pacing therapy (APT), cognitive behaviour therapy (CBT), or graded exercise therapy (GET), to specialist medical care (SMC) for patients with chronic fatigue syndrome.
Anthony L. Johnson (124576), McCrone Paul, Trudie Chalder (37639), Johnson Anthony L., Peter D White, Kimberley A Goldsmith, Chalder Trudie, Peter D. White (146167), Goldsmith, Kimberley A., Paul McCrone (121370), McCrone, P, Knapp, M, Martin Knapp (146158), Knapp, Martin, Goldsmith, Kimberley; id_orcid, Chalder, Trudie; id_orcid, Goldsmith, KA, McCrone, Paul R., Sharpe, M, Paul McCrone, Michael Sharpe (146153), Johnson, AL, White Peter D., Goldsmith Kimberley A., Johnson, Anthony L., Sharpe Michael, White, Peter D., Michael Sharpe, Sharpe, Michael, Trudie Chalder, Chalder, Trudie, Knapp Martin, White, PD, Kimberley A. Goldsmith (146164), McCrone, Paul, Anthony L Johnson, Martin Knapp, Chalder, T   +37 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Oesophageal Injury in Traumatic Pneumomediastinum: A Review of the Past 11 Years in an Upper Gastrointestinal Specialist Centre. [PDF]

Cureus, 2022
Shehata Z, Shetty VD.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Types of parents’ involvement in early childhood development

Psychiatria i Psychologia Kliniczna, 2016
Depending on their involvement in assisting their child’s development, parents may have various chances of improving and refining their childcare, parenting, and therapeutic methods.
Barbara Chojnacka-Synaszko
doaj   +1 more source

Retrospective Analysis of Clinical Outcomes of Stereotactic Body Radiation Therapy for Localized Prostate Cancer at an Asian Cancer Specialist Centre. [PDF]

Asian Pac J Cancer Prev, 2023
Pei Yuin JL, Jia Shin JT, Jing CB, Mun TL, Balasubramaniam MA, Ibrahim Wahid DM.   +5 more
europepmc   +1 more source

The relationship between alcohol-related hospital admission and specialist alcohol treatment provision across local authorities in England since passage of the Health and Social Care Act 2012.

, 2020
To our knowledge no previous studies have been conducted at the local authority level assessing relationships between alcohol-related hospital admission, specialist alcohol treatment provision and socioeconomic deprivation since the UK government passed ...
Hotopf, Matthew, Drummond, Colin, Roberts, Emmert   +2 more
core   +1 more source