Results 81 to 90 of about 193,296 (299)

Clinical nurses’ perceived educational value of nursing journal clubs

BMC Nursing
Background Evidence-based practice plays a pivotal role in modern nursing decision-making. Healthcare organizations must ensure that nurses consistently have access to and apply the most current evidence.
Jennifer de Beer, Elham Alsanea, Joynalyn Barrios, Shahd Brnawi, Wejdan Barayan, Wadea Beheri, Emily Lenore Heaphy   +6 more
doaj   +1 more source

Truncating ARL6IP1 variant as the genetic cause of fatal complicated hereditary spastic paraplegia

BMC Medical Genetics, 2019
Background Mutations in ARL6IP1, which encodes a tetraspan membrane protein localized to the endoplasmic reticulum (ER), have been recently described in a large family with a complicated form of hereditary spastic paraplegia (HSP).
Salma M. Wakil, Safa Alhissi, Haya Al Dossari, Ayesha Alqahtani, Sherin Shibin, Brahim T. Melaiki, Josef Finsterer, Amal Al-Hashem, Saeed Bohlega, Anas M. Alazami   +9 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Multiagency response to childhood sexual abuse: a case study that explores the role of a specialist centre

, 2017
Through the application of case study methods, this research explored the role of a specialist centre that responds to actual or suspected childhood sexual abuse (CSA).
Powell, Catherine, Catherine Powell, Voss, Lindsay, Helen Rushforth, Rushforth, Helen, Lindsay Voss   +5 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Service specification Specialist rehabilitation centre

, 1997
SIGLEAvailable from British Library Document Supply Centre-DSC:98/03828 / BLDSC - British Library Document Supply CentreGBUnited ...
Lo, S.V., Bro Taf Health Authority, Cardiff (United Kingdom). Specialist Commissioning Team   +1 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Managing Medical Records in Specialist Medical Centres

International Journal of Engineering and Technology, 2018
A collection of facts about a patient’s life and health history of past and present illnesses and treatments is known as medical records. The health professionals were contributing to record the patient’s care. The responsibility in managing daily records that produced by each of department is by the Medical Records Department. It is a department under
Mastura Md Zali, Saiful Farik Mat Yatin, Mohd Razilan Abdul Kadir, Siti Noraini Mohd Tobi, Nurul Hanis Kamarudin, Nik Nurul Emyliana Nik Ramlee   +5 more
openaire   +2 more sources

Estia Centre 10 Years

, 2010
In 2009, the Estia Centre celebrates a decade of working \ud towards making sure the mental health needs of people \ud with learning disabilities are met – through specialist \ud clinical services, research, and a programme of training \ud and education ...
Centre, Estia
core