Results 71 to 80 of about 193,296 (299)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

THERACOM : a systematic review of the evidence base for interventions to improve Therapeutic Communications between black and minority ethnic populations and staff in specialist mental health services [PDF]

, 2013
Background: Black and Minority Ethnic (BME) groups in receipt of specialist mental health care have reported higher rates of detention under the mental health act, less use of psychological therapies, and more dissatisfaction.
Johnson, Mark, Singh, S., McCabe, R, Kamaldeep Bhui, Johnson, M., Swaran Singh, Weich, S., Bhui, Kamaldeep S., McCabe, R., Bhui, Kamaldeep, McCabe, Rosemarie, Weich, S, McCabe, Rose, Szczepura, A, Scott Weich, Szczepura, A., Rosemarie McCabe, Szczepura, Ala; id_orcid, Szczepura, Ala, Singh, S, Johnson, Mark R. D., Johnson, M, Bhui, K, Bhui, K., Singh, Swaran P., Ala Szczepura, Mark Johnson, Weich, Scott   +27 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Surgical Site Infection After Breast Surgery—A Bicentric Retrospective Case–Control Study in Saudi Arabia

Clinics and Practice
Background: Surgical site infections (SSIs) are common postoperative complications. Data on SSIs following breast surgery in Saudi Arabia are limited because these procedures are not included in the national SSI surveillance system. This study determined
Moteb AlSaadi, Salem Alghamdi, Fayyaz Mazari, Sabah Alshuhri, Rustom Bashtawi, Raghad Aljehani, Basmah Alwuqaisi, Rawan Almohammadi, Mahmoud Alfirikh, Sameer Desai, Ebrahim Mahmoud   +10 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Pharmacogenomic testing implementation: Tertiary care center experience and results of a pilot of 512 patients

Genetics in Medicine Open
Purpose: Pharmacogenomic (PGx) testing has proven significant clinical utility in minimizing adverse drug reactions and maximizing therapeutic effects.
Dana Bakheet, Hana Al Alshaykh, Ghadi Askar, Sateesh Maddirevula, Samya Hagos, Nasir Hamad Alshahrani, Midrar Alhusseini, Amani Moharram, Faries Algadhi, Osama Alswailim, Moatasem Alsulaim, Bandar Alamro, Fadl Elmula Mohamed Fadl Elmula, Bahadur Khan, Ahmed Almustafa, Ahmed Alshehri, Dimpna Brotons, Fahad Alajlan, Mohammed Alnahedh, Abdullah Alsuwaidan, Salah Baz, Ahmed Alfares   +21 more
doaj   +1 more source

Giant cell tumor of bone following denosumab treatment: assessment of tumor response using various imaging modalities

Insights into Imaging, 2020
Background Giant cell tumor (GCT) is a nonmalignant neoplasm composed of multinucleated giant and mononuclear stromal cells. This study aimed to compare imaging findings of GCT pre- and post-denosumab treatment, including lesion size, percentage of ...
Maram Alothman, Waleed Althobaity, Yasser Asiri, Saleh Alreshoodi, Khalid Alismail, Meshal Alshaalan   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Misy Sunshine Specialist Centre / Norazian Ahmad... [et al.] [PDF]

, 2000
Misy Sunshine Specialist Centre is a partnership business who runs services such as obstetrician, gynologist and outdoor patient. They were located at Kangar Perlis.
Hashim, Siti Hazarotul, Mohd Radzi, Tengku Memy Nazhafifa, Ahmad, Norazian, Othman, Noor Hasniza Othman   +3 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source