Results 51 to 60 of about 99,252 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effectiveness of a Structured Self-Management Intervention to Improve Quality of Life in Individuals With Chronic Obstructive Pulmonary Disease (AMPOC Study)

Open Respiratory Archives
Introduction: This study aimed to compare the effectiveness of a structured self-management program in patients with moderate–severe COPD followed up for 12 months, in improving quality of life, dyspnea, inhaler adherence, anxiety, and depression ...
Maite López Luque, Marta Chuecos Molina, Guadalupe Ortega Cuelva, M. Jesús Vázquez López, Francisco Orfila Pernas, Nina Granel Giménez, Esther Ruiz Rodríguez, M. Ángeles Santos Santos, Adrià Almazor Sirvent, Antonio Vallejo Domingo, Toni López Ruiz, Purificación Jordana Ferrando   +11 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The nursing contribution to chronic disease management: a whole systems approach: Report for the National Institute for Health Research Service Delivery and Organisation programme [PDF]

, 2010
Background Transforming the delivery of care for people with Long Term Conditions (LTCs) requires understanding about how health care policies in England and historical patterns of service delivery have led to different models of chronic disease ...
Kendall, Sally, McNeilly, Elaine, Wilson, Patricia M., Bunn, Frances, Brooks, Fiona, Procter, Susan, Gage, Heather   +6 more
core  

Supportive care for patients with oesophageal and other upper gastrointestinal cancers: The role of a specialist nurse in the team

, 2006
Summary The care pathway of patients with upper gastrointestinal cancers is complex. We retrospectively evaluated the patients’ opinions of support and supportive care given by a specialist nurse who led the care of such patients.
Lagergren, Jesper, Viklund, Pernilla, Wengström, Yvonne,, Lagergren, Jesper,, Viklund, Pernilla,, Wengstrom, Yvonne   +5 more
core   +1 more source

A New Primary Care Model Based on Population Needs: A Nationwide Cross-Sectional Study

Nursing Reports
Background/Objectives: The role of the primary health care nurse has evolved since the Spanish Ministry of Health officially established the professional profile of the nurse specialist in Primary Health Care in 2005.
Silvia Domínguez Fernández, Pedro García Martínez, María Isabel Mármol-López, Esther Nieto García, María Begoña Sánchez Gómez, Mª Guadalupe Fontán Vinagre, Diego Ayuso-Murillo, Susana Montenegro Méndez, Francisco Javier Pérez-Rivas   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source