Results 121 to 130 of about 262,521 (313)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Unicuspid aortic valve with false aortic dissection appearance: A case report

Türk Kardiyoloji Derneği Arşivi, 2021
Barkın Kültürsay, Berhan Keskin, Seda Tanyeri, Ali Karagöz, Cihangir Kaymaz   +4 more
doaj   +1 more source

A Bioreactor for Celullarised Membrane Culture and Delivery under Sterile Conditions

Bioengineering
A novel, user-friendly bioreactor for the cultivation of cellularised membranes for tissue engineering has been successfully designed, manufactured, and validated.
Ainitze Gereka, Uzuri Urtaza, Pablo Larreategi, Felipe Prosper, Enrique José Andreu, Ane Miren Zaldua   +5 more
doaj   +1 more source

To specialize or too specialized?

Canadian Medical Education Journal, 2013
In January of 2011 I, together with my fourth-year medical student colleagues, returned to the University of Western Ontario from our electives to begin four months of preparation for our medical licensing exam. During large group discussions on general clinical scenarios, it was clear that, for most students, specialization was well underway.
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Specialization, Information, and Growth: A Sequential Equilibrium Analysis [PDF]

Pricing costs and information problems are introduced into a framework with consumer-producers, economies of specialization, and transaction costs to predict the endogenous and concurrent evolution in division of labor and in the information of ...
Yew-Kwang Ng, Xiaokai Yang
core  

The Association between Parents' Beliefs About Youth Sport Specialization and their Children's Specialization Status

, 2021
Despite the many preeminent national and international sports authorities who strongly discourage youth sport specialization, many children are specializing in a single sport.
Strosser, Stephen.
core   +1 more source

First worldwide use of the hybrid system for extracorporeal circulation in heart transplant

Journal of Cardiothoracic Surgery
Background This case report documents the first worldwide use of the Hybrid System from Spectrum Medical in a heart transplant procedure, focusing on its safety and efficacy.
Kaan Kırali, Mehmet Aksüt, Özge Altaş, Mustafa Emre Gürcü, Sibel Aydın   +4 more
doaj   +1 more source

Prognostic Value of the CALLY Index in Predicting All-Cause Mortality After Transcatheter Aortic Valve Implantation: A Two-Year Follow-Up Study

Medicina
Background and Objectives: This study investigated the prognostic value of the C-reactive protein–albumin–lymphocyte (CALLY) index in predicting all-cause mortality among patients undergoing transcatheter aortic valve implantation (TAVI) for severe ...
Zeynep Esra Güner, İsmail Balaban, Mustafa Ferhat Keten, Rıdvan Bolataslan, Ravza Betül Akbaş, Seda Tanyeri Üzel, Regayip Zehir, Elnur Alizade   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source