Results 151 to 160 of about 216,681 (315)
Effect of Pre-Operative Glycaemic Control on the Outcomes of AV Fistula Surgery in Diabetic Patients
EJVES Vascular Forum, 2023 H. HanÇer +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Paths of Development, Specialization, and Natural Resources Abundance [PDF]
This paper addresses three main questions; how can a country specialized in primary goods become an exporter of manufacturing goods? How does factor abundance affect the possibilities of achieving comparative advantages in manufactures?
Roberto Álvarez, Rodrigo Fuentes
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Technology, Trade Specialization and Development: Jumping to Technology Development Era [PDF]
Developing countries often are characterized as producers and exporters of a few types of natural resource based goods. Intuition dictates that these countries should change their strategy from being merely merchandise producers to technology developers ...
Mellati, Ali
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Export Diversification and Specialization in South Africa: Extent and Impact [PDF]
Should developing countries focus on diversifying their export basket or should they instead specialize their exports according to their existing comparative advantage?
Naude, Wim, Rossouw, Riaan
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Integration, Regional Specialization and Growth Differentials in EU Acceding Countries: Evidence from Hungary [PDF]
This paper investigates the impact of market integration on regional production structures and regional growth differentials in Hungary over the period 1994-2000.
Iulia Traistaru, Anna Iara
core