Results 51 to 60 of about 705,077 (307)

Effectivness of specific mobile health applications (mHealth-apps) in gestational diabtetes mellitus: a systematic review

BMC Pregnancy and Childbirth, 2021
Background Gestational diabetes mellitus (GDM) emerges worldwide and is closely associated with short- and long-term health issues in women and their offspring, such as pregnancy and birth complications respectively comorbidities, Type 2 Diabetes (T2D ...
Claudia Eberle, Maxine Loehnert, Stefanie Stichling   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Migraine diagnosis in patients with sinus headache symptoms: a cross-sectional study at Khartoum ENT Hospital

The Egyptian Journal of Otolaryngology
Background Sinus headache is the most common diagnosis reported by patients with migraine who received a non-migraine diagnosis. Thus, the aim of this study was to determine the prevalence of migraine among patients present with sinus headache to ...
Mohamed Salah Mohamed Abdelgafour, Abdelgadir Ahmed Eltayeb, Mohammed El-Awad   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Ileocecal volvulus in an infant with dorsal mesenteric agenesis: A case report

Journal of Pediatric Surgery Case Reports
Introduction: Intestinal volvulus due to agenesis of the dorsal mesentery is an exceptionally rare cause of intestinal obstruction in infants, with few cases reported in the literature.
Alaa Eltayeb, Abdelrahman S. Elnour, Rammah Bireama, Yousif Faisal, Faisal Nugud   +4 more
doaj   +1 more source

PRODUCTIVE SPECIALIZATION AND REGIONAL DEVELOPMENT IN PORTUGAL AT THE NUTS III LEVEL [PDF]

The purpose of this paper is to analyse how the specialization of Portuguese productive structures has evolved between 1995 and 2004, using specialization indicators, namely localization quotient estimation, to assess both the relative degree of ...
Francisco Diniz
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Practical Approach to SARS-CoV-2 Prevention and Containment in a National Sporting Event in Italy: A Public Health Model Applicable Also to Other Respiratory Viruses?

COVID
The Italian sporting event ‘XIV Convittiadi’ involving students at boarding schools took place in Molise region, central Italy, in April 2022. The study describes the public health protocol with specific countermeasures developed for the event, including
Roberta De Dona, Manuela Tamburro, Carmen Adesso, Angelo Salzo, Antonio D’Amico, Nicandro Samprati, Arturo Santagata, Michela Anna Di Palma, Anna Natale, Fabio Cannizzaro, Vittorio Viccione, Giancarlo Ripabelli   +11 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source