Results 71 to 80 of about 120,119 (269)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Split Personality of a Potyvirus: To Specialize or Not to Specialize?
PLoS ONE, 2014 Bean yellow mosaic virus (BYMV), genus Potyvirus, has an extensive natural host range encompassing both dicots and monocots. Its phylogenetic groups were considered to consist of an ancestral generalist group and six specialist groups derived from this generalist group during plant domestication. Recombination was suggested to be playing a role in BYMV'
Monica A Kehoe +3 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Special Holonomy on Special Spaces
, 2014 We characterise simply-connected biquotients which potentially admit metrics of holonomy G_2. We prove that there are at most three real homotopy types of rationally elliptic such manifolds---all of them being formal. In the course of this examination we classify rationally elliptic homotopy types and characterise 7-dimensional simply-connected ...
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Special monoids and special thue systems
Journal of Algebra, 1987 A special monoid is a monoid with defining relations of the form \(w=1\). The authors prove in the context of Thue systems that for two special monoids \(M_ 1\) and \(M_ 2\) with a bijective correspondence of their generators the following holds: If any congruence class \([x]_{M_ 1}\) equals the congruence class \([x]_{M_ 2}\) for \(M_ 2\) then the two
McNaughton, R, Narendran, P
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Flashbulb memories: Special, but not so special [PDF]
Memory & Cognition, 1989 This study deals with flashbulb memories associated with the assassination of the Swedish prime minister Olof Palme. A major goal of this research was to explore the consistency of such memories through comparison of the subjects' recollections on two different occasions, one year apart.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source