Results 81 to 90 of about 697,557 (339)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga   +8 more
wiley   +1 more source

Stability, Specialization and Social Recognition [PDF]

open access: yes
Yang s theory of economic specialization under increasing returns to scale (Yang 2001) is a formal development of the fundamental Smith-Young theorem on the extent of the market and the social division of labor.In this theory specialization and, thus ...
Gilles, R.P.   +2 more
core   +1 more source

Comparison of Stone Scoring Systems in Predicting Outcomes of Percutaneous Nephrolithotomy in Patients with Solitary Kidney

open access: yesJournal of Urological Surgery, 2020
Objective:To assess efficacy of the Guy’s Stone score (GSS) and Clinical Research Office of the Endourological Society (CROES) nomogram in predicting outcomes of percutaneous nephrolithotomy (PCNL) in patients with solitary kidney.Materials and Methods ...
Volkan Çağlayan   +5 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Special Delivery [PDF]

open access: yesWestern Journal of Emergency Medicine, 2014
[West J Emerg Med. 2014;15(6):627–628.]
openaire   +5 more sources

The Dynamics of Economic Policy and Regional Specialization: Evidence from China¡¯s High-tech Industry [PDF]

open access: yes
: This paper investigates the effects of economic policy on regional specialization of China¡¯s high-tech industries for the period 1996 to 2005. Results indicate that the average level of regional specialization increases over years.
Dan Zheng
core  

First worldwide use of the hybrid system for extracorporeal circulation in heart transplant

open access: yesJournal of Cardiothoracic Surgery
Background This case report documents the first worldwide use of the Hybrid System from Spectrum Medical in a heart transplant procedure, focusing on its safety and efficacy.
Kaan Kırali   +4 more
doaj   +1 more source

A Bioreactor for Celullarised Membrane Culture and Delivery under Sterile Conditions

open access: yesBioengineering
A novel, user-friendly bioreactor for the cultivation of cellularised membranes for tissue engineering has been successfully designed, manufactured, and validated.
Ainitze Gereka   +5 more
doaj   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

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