Results 61 to 70 of about 880,646 (268)
Евразийский Кардиологический Журнал, 2016 Aim: to study hypotensive and organo-protective efficacy of cornbination therapy with perindopril and indanarnide in patients with rnild and rnoderate arterial hypertension. Material and methods.
G. J. Abdullayeva +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Евразийский Кардиологический Журнал, 2017 Objective. The questions of female health last years get the increasing urgency cardiovascular disease occupy a leading place in structure смертности from the women in the different countries. Often risk of development cardiovascular disease at the women
D. E. Abidova +3 more
doaj +1 more source
Special Kids, Special Parents, Special Education
University of Michigan Journal of Law Reform, 2014 Many parents are raising children whose mental, physical, cognitive, emotional, or developmental issues diminish their capacity to be educated in the same ways as other children. Over six million of these children receive special education services under mandates of the Individuals with Disabilities Education Act, called the IDEA. Once largely excluded
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
RESULTS OF OFF-PUMP MYOCARDIAL REVASCULARIZATION IN PATIENTS WITH LV EJECTION FRACTION <45 %
Евразийский Кардиологический Журнал, 2019 Conventional on-pump coronary artery bypass grafting operations in patients with compromised left ventricular (LV) systolic function are accompanied by high rates of morbidity and mortality.
I. M. Sharipov +5 more
doaj
PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION
Евразийский Кардиологический Журнал, 2014 The aim of the study. Comparative analysis of the risk assessment of thromboembolism by CHADS2 and CHA2DS2-VASc scores, and to study the preventive effectiveness of different antithrombotic agents in patients with long-lasting аtrial fibrillation (AF) at
R. D. Kurbanov +3 more
doaj +1 more source
Split Personality of a Potyvirus: To Specialize or Not to Specialize?
PLoS ONE, 2014 Bean yellow mosaic virus (BYMV), genus Potyvirus, has an extensive natural host range encompassing both dicots and monocots. Its phylogenetic groups were considered to consist of an ancestral generalist group and six specialist groups derived from this generalist group during plant domestication. Recombination was suggested to be playing a role in BYMV'
Monica A Kehoe +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source