Results 151 to 160 of about 501,668 (378)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans

iScience
Summary: Muscle contraction is vital for animal survival, and the sarcomere is the fundamental unit for this process. However, the functions of many conserved sarcomere proteins remain unknown, as their mutants do not exhibit obvious defects.
Ling Jiang, Xinyan Wang, Dandan Zhang, Karen Wing Yee Yuen, Yu Chung Tse   +4 more
doaj   +1 more source

Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program

iScience, 2019
Summary: Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients and likely affects their differentiation, a process that remains poorly defined.
Cristina Sánchez-de-Diego, Natalia Artigas, Carolina Pimenta-Lopes, José Antonio Valer, Benjamin Torrejon, Pau Gama-Pérez, Josep A. Villena, Pablo M. Garcia-Roves, José Luis Rosa, Francesc Ventura   +9 more
doaj   +1 more source

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos [PDF]

, 2009
Michelle A. Linterman, Robert J. Rigby, Raphael. K. Wong, Diego Afonso Silva, David R. Withers, Graham Anderson, Naresh K. Verma, Robert Brink, Andreas Hutloff, Christopher C. Goodnow, Carola G. Vinuesa   +10 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Modeling hepatic steatosis with human adult stem cell-derived liver organoids

iScience
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) remains the most common chronic liver disease worldwide, and appropriate in vitro models are of great significance for investigating pathogenesis and drug screening of MASLD.
Liuyang Zhu, Sen Liu, Ze Wang, Yueyue Yang, Pinsheng Han, Wen Tong, Tianyu Zhao, Libo Wang, Tao Cui, Long Yang, Yamin Zhang   +10 more
doaj   +1 more source

Cell function and specialization

, 2009
Analiza las células animales y vegetales, sus diferentes partes, y la función de cada una de estas partes. Los estudiantes entre once y catorce años aprenderán cuántas células se encuentran en el cuerpo humano, cómo funciona un flagelo o cómo una célula obtiene energía.
openaire   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Papilloma protein E6 abrogates shear stress-dependent survival in human endothelial cells: Evidence for specialized functions of paxillin [PDF]

, 2006
Stefania Mattiussi, Kenji Matsumoto, Barbara Illi, Fabio Martelli, M. C. Capogrossi, Carlo Gaetano   +5 more
openalex   +1 more source

Reliability models applicable to space telescope solar array assembly system [PDF]

A complex system may consist of a number of subsystems with several components in series, parallel, or combination of both series and parallel. In order to predict how well the system will perform, it is necessary to know the reliabilities of the ...
Patil, S. A.
core   +1 more source