Results 31 to 40 of about 503,791 (335)
Lens regeneration in situ using hESCs-derived cells —similar to natural lens
iScience, 2023 Summary: Lens itself has limited regeneration functionality, thus we aimed to create regenerated lens with biological function to treat cataracts rather than the intraocular lens used in cataract surgery.
Xinyi Chen +9 more
doaj +1 more source
iScience, 2023 Summary: Hepcidin is the master hormone governing systemic iron homeostasis. Iron regulates hepcidin by activating bone morphogenetic protein (BMP)6 expression in liver endothelial cells (LECs), but the mechanisms are incompletely understood.
Allison L. Fisher +9 more
doaj +1 more source
iScience, 2023 Summary: The FliG protein plays a pivotal role in switching the rotational direction of the flagellar motor between clockwise and counterclockwise. Although we previously showed that mutations in the Gly-Gly linker of FliG induce a defect in switching ...
Tatsuro Nishikino +6 more
doaj +1 more source
iScience, 2020 Summary: Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types.
Paula J. Bartlett +3 more
doaj +1 more source
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts
iScience, 2023 Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang +9 more
doaj +1 more source
Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes
iScience, 2023 Summary: Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1).
Chad C. Doucette +9 more
doaj +1 more source
eLife, 2014 Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions.
Joan Isern +7 more
openalex +5 more sources
Flagellar membrane association via interaction with lipid rafts [PDF]
, 2009 The eukaryotic flagellar membrane has a distinct composition from other domains of the plasmalemma. Our work shows that the specialized composition of the trypanosome flagellar membrane reflects increased concentrations of sterols and saturated fatty ...
Cieslak, John A. +6 more
core +2 more sources
Functional Specialization of Memory Th Cells Revealed by Expression of Integrin CD49b [PDF]
The Journal of Immunology, 2006 Abstract Infection or immunization induces heterogeneous memory T cell subsets, but their origin and protective value against infection are unclear. In this study, we report the functional characterization of two memory Th subsets, defined by expression of integrin CD49b. Stable CD49b expression is induced in up to one-half of all memory
Kassiotis, George +4 more
openaire +3 more sources
Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
iScience, 2023 Summary: Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects.
JingJing Shang +7 more
doaj +1 more source