Results 31 to 40 of about 212,832 (300)

Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq

iScience, 2023
Summary: T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore ...
Hui Li, Hongyi Liu, Yifei Liu, Xuefei Wang, Shiya Yu, Hongwen Huang, Xiangru Shen, Qi Zhang, Ni Hong, Wenfei Jin   +9 more
doaj   +1 more source

Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression

iScience, 2020
Summary: Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation.
Maria C. Demaria, Louisa Yeung, Rens Peeters, Janet L. Wee, Masa Mihaljcic, Eleanor L. Jones, Zeyad Nasa, Frank Alderuccio, Pamela Hall, Brodie C. Smith, Katrina J. Binger, Gunther Hammerling, Hang Fai Kwok, Andrew Newman, Ann Ager, Annemiek van Spriel, Michael J. Hickey, Mark D. Wright   +17 more
doaj   +1 more source

CircMAPK9 promotes adipogenesis through modulating hsa-miR-1322/FTO axis in obesity

iScience, 2023
Summary: Circular RNA (circRNA) is a special category of non-coding RNA that has garnered increasing attention in the exploration of lipid metabolism. However, the functional regulation mechanisms of circRNAs in obesity diseases remain unclear.
Shuai Chen, Peng Song, Yu Wang, Zeng Wang, Jiaming Xue, Yicheng Jiang, Yan Zhou, Jie Zhao, Liming Tang   +8 more
doaj   +1 more source

AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion

iScience, 2023
Summary: Due to the post-mitotic nature of skeletal muscle fibers, adult muscle maintenance relies on dedicated muscle stem cells (MuSCs). In most physiological contexts, MuSCs support myofiber homeostasis by contributing to myonuclear accretion, which ...
Anita Kneppers, Sabrina Ben Larbi, Marine Theret, Audrey Saugues, Carole Dabadie, Linda Gsaier, Arnaud Ferry, Philipp Rhein, Julien Gondin, Kei Sakamoto, Rémi Mounier   +10 more
doaj   +1 more source

Functional specialization of gut CD103 + dendritic cells in the regulation of tissue-selective T cell homing [PDF]

The Journal of Experimental Medicine, 2005
Gut-associated lymphoid tissue (GALT) dendritic cells (DCs) display a unique ability to generate CCR9+α4β7+ gut-tropic CD8+ effector T cells. We demonstrate efficient induction of CCR9 and α4β7 on CD8+ T cells in mesenteric lymph nodes (MLNs) after oral but not intraperitoneal (i.p.) antigen administration indicating differential targeting of DCs via ...
Johansson-Lindbom, Bengt, Svensson, Marcus, Pabst, Oliver, Palmqvist, Caroline, Marquez, Gabriel, Förster, Reinhold, Agace, William W.   +6 more
openaire   +2 more sources

Multiple Functions of Malpighian Tubules in Insects: A Review

Insects, 2022
The Malpighian Tubules (MTs) are the main excretory organs in most insects. They play a key role in the production of primary urine and osmoregulation, selectively reabsorbing water, ions, and solutes.
Priscilla Farina, Stefano Bedini, Barbara Conti   +2 more
doaj   +1 more source

Special Issue “Disentangling Mechanisms of Genomic Regulation of Cell Functions at the Gene Level” [PDF]

Genes, 2020
The term “gene” was introduced more than a hundred years ago to define a “fundamental physical and functional unit of heredity” [...]
Hans Binder, Arsen Arakelyan
openaire   +3 more sources

Bmal1 deletion alters mitochondrial microstructure and function in mouse cone photoreceptors

iScience
Summary: The mammalian retina contains an autonomous circadian system that regulates ocular physiology. The deletion of the core clock gene Bmal1 in the mouse retina disrupts retinal circuitry, alters cone spectral identity, and reduces cone viability ...
Nicolas Diaz, Sondip Biswas, Wei Zhong, Khaleel Bashir, Ting Chung Suen, Jason DeBruyne, Paul Michael Iuvone, Gianluca Tosini, Hao Duong, Sharon Francis, Kenkichi Baba   +10 more
doaj   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

The matricellular protein ADAMTS-like 2 regulates differentiation of skeletal muscle-resident fibro-adipogenic progenitor cells

iScience
Summary: Skeletal muscle development and regeneration requires the activities of myogenic and non-myogenic muscle stem cell populations. Non-myogenic muscle stem cells, such as fibro-adipogenic progenitors (FAPs), play important roles in muscle ...
Charlene Redhead, Nandaraj Taye, Britney Chin-Young, Kasoorelope Oguntuyo, James H. Cummins, Kevin J. Hart, Woojin M. Han, Dirk Hubmacher   +7 more
doaj   +1 more source