Results 41 to 50 of about 427,855 (303)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Medical Infographics: Resemiotization Strategies in Specialized Discourse

open access: yes, 2020
This chapter addresses the spreading genre of digital infographics, i.e., the conflation of visual and verbal language in the graphic visualization of specific sets of data, information and knowledge, so as to facilitate, accelerate and disseminate ...
Consonni, Stefania (ORCID:0000-0001-6221-4272)
core   +1 more source

Methods of quantifying specialized knowledge and network rewiring

open access: yes, 2023
Technological innovations are a major driver of economic development that depend on the exchange of knowledge and ideas among those with unique but complementary specialized knowledge and knowhow. However, measurement of specialized knowledge embedded in
Macy, Michael, Nee, Victor, Wang, Sirui
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Intellectual Property Investigations: A New Area of Forensic Practice in the System of the Russian Ministry of Justice

open access: yesТеория и практика судебной экспертизы, 2018
The paper examines the background for the establishment of forensic investigation of intellectual property as a new area of forensic practice in the system of forensic science organizations of the Russian Ministry of Justice.
Svetlana A. Smirnova   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Subject of Forensic Facial Recognition

open access: yesТеория и практика судебной экспертизы, 2018
The paper examines some key concepts of forensic science, namely the subject, object and objectives of investigation, in terms of how they are defined and how they relate to each other.
I. N. Podvolotskii
doaj   +1 more source

Why Knowledge is Special

open access: yesPhilosophy, 2017
AbstractI argue against Greco's account of the value of knowledge, according to which knowledge is distinctively valuablevis-à-visthat which falls short of knowledge in virtue of its status as an achievement and achievements being finally valuable. Instead, I make the case that virtuous belief is also an achievement.
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Investigation of Gaming Equipment Used in Illegal Gambling Operations

open access: yesТеория и практика судебной экспертизы, 2018
The article deals with certain aspects of investigating criminal cases related to illegal organization and operation of games of chance. The focus is on the application of various procedural forms of using specialized knowledge in computer technology, as
A. G. Sebyakin
doaj   +1 more source

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