Results 251 to 260 of about 325,721 (301)

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

A special issue on 'Metabolism'.

Acta biochimica et biophysica Sinica, 2013
openaire   +1 more source

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Plant specialized metabolism

Current Biology, 2023
Environmental factors such as light, water, minerals, temperature, and other organisms affect plant growth and development. Unlike animals, plants can't escape from unfavorable biotic and abiotic stresses. Thus, they evolved the ability to biosynthesize specific chemicals referred to as plant specialized metabolites in order to facilitate successful ...
Xing-Qi, Huang, Natalia, Dudareva
openaire   +2 more sources

Heterogeneity in Bacterial Specialized Metabolism

Journal of Molecular Biology, 2019
Specialized metabolites (SMs) like typical antibiotics, signaling molecules or other bioactive compounds of bacterial origin (sometimes also used in human therapy) are often complex natural products that are costly for the cell to make. Several bacterial taxa are known to produce multiple SM classes in parallel and therefore a division of labor within ...
Tobias, N., Bode, H.
openaire   +3 more sources

Specialized metabolism and development: An unexpected friendship

Current Opinion in Plant Biology, 2021
Plants produce a myriad of metabolites. Some of them have been regarded for a long time as secondary or specialized metabolites and are considered to have functions mostly in defense and the adaptation of plants to their environment. However, in the last years, new research has shown that these metabolites can also have roles in the regulation of plant
Yolanda, Durán-Medina, Beatriz Esperanza, Ruiz-Cortés, Herenia, Guerrero-Largo, Nayelli, Marsch-Martínez   +3 more
openaire   +2 more sources

Convergent Evolution in Plant Specialized Metabolism

Annual Review of Plant Biology, 2011
Plants synthesize a multitude of compounds that contribute to adaptation to their ecological niches. Such compounds serve as attractants of other living organisms beneficial to the plants or as defense against other biotic as well as abiotic agents.
Eran, Pichersky, Efraim, Lewinsohn
openaire   +2 more sources

Tryptophan metabolism in special pairs of twins

Clinica Chimica Acta, 1964
Abstract In 4 twin pairs, each consisting of a schizophrenic sibling and a normal sibling, tryptophan metabolism was studied after a loading test. Seven out of 8 subjects showed an abnormal metabolites excretion, higher than that observed in the chronic schizophrenic patients previously studied.
C A, BENASSI, G, ALLEGRI, P, BENASSI, A, RABASSINI   +3 more
openaire   +2 more sources

Introduction to plant specialized metabolism

2016
Introduction to plant specialized ...
Arimura, G. I, MAFFEI, Massimo Emilio
openaire   +3 more sources