Results 31 to 40 of about 157,597 (264)

Effectiveness and Safety of Add-on Once-Daily Liraglutide (1.2 mg) in Type 2 Diabetes Patients with Obesity: Data from a Real-World Cohort of Iraqi Patients

Clinical Diabetology
OBJECTIVE: This study aimed to evaluate real-world effectiveness and safety of once-daily liraglutide (1.2 mg) as an add-on to oral antidiabetic drugs (OADs) and/or insulin, in type 2 diabetes (T2D) patients with obesity in Iraq. MATERIALS AND METHODS: A
Haider Ayad Alidrisi, Sameh Abed Odhaib, Hussein Ali Nwayyir, Ammar Mohammed Saeed Almomin   +3 more
doaj   +1 more source

An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications

Molecules, 2022
Benzophenanthridines belong to the benzylisoquinolic alkaloids, representing one of the main groups of this class. These alkaloids include over 120 different compounds, mostly in plants from the Fumariaceae, Papaveraceae, and Rutaceae families, which ...
José Ignacio Laines-Hidalgo, José Armando Muñoz-Sánchez, Lloyd Loza-Müller, Felipe Vázquez-Flota   +3 more
doaj   +1 more source

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

eLife, 2019
Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing Streptomyces. Streptomyces species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has
Emma J Gehrke, Xiafei Zhang, Sheila M Pimentel-Elardo, Andrew R Johnson, Christiaan A Rees, Stephanie E Jones, Hindra, Sebastian S Gehrke, Sonya Turvey, Suzanne Boursalie, Jane E Hill, Erin E Carlson, Justin R Nodwell, Marie A Elliot   +13 more
doaj   +1 more source

Gene clustering in plant specialized metabolism

Current Opinion in Biotechnology, 2014
Physically linked clusters of genes that encode the enzymatic information for the synthesis of specialized metabolites are a well-established feature of microbial secondary metabolism. In contrast, the biosynthesis of plant specialized metabolites has until recently been thought to be almost exclusively encoded by genes that are randomly scattered in ...
Nützmann, Hans-Wilhelm, Osbourn, Anne
openaire   +2 more sources

An Integrated Analytical Approach Reveals Trichome Acylsugar Metabolite Diversity in the Wild Tomato Solanum pennellii

Metabolites, 2020
Acylsugars constitute an abundant class of pest- and pathogen-protective Solanaceae family plant-specialized metabolites produced in secretory glandular trichomes.
Daniel B. Lybrand, Thilani M. Anthony, A. Daniel Jones, Robert L. Last   +3 more
doaj   +1 more source

Ecological convergence in phytochemistry and flower–insect visitor interactions along an Andean elevation gradient

Ecology and Evolution, 2023
The diversity of specialized molecules produced by plants radiating along ecological gradients is thought to arise from plants' adaptations to local conditions.
Alma Nalleli Carvajal Acosta, Ludovico Formenti, Adrienne Godschalx, Angelos Katsanis, Constanza Schapheer, Kailen Mooney, Cristian Villagra, Sergio Rasmann   +7 more
doaj   +1 more source

Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes

Frontiers in Plant Science, 2017
Cytochrome P450 monooxygenases (P450s) represent the largest enzyme family of the plant metabolism. Plants typically devote about 1% of the protein-coding genes for the P450s to execute primary metabolism and also to perform species-specific specialized ...
Sumit Ghosh
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Sexual dysfunction in women with newly diagnosed thyroid dysfunction: a novel report from Basrah, Iraq

Journal of Biological Research
Thyroid dysfunction has been proposed as a potential contributor to Female Sexual Dysfunction (FSD), yet its impact, particularly in subclinical and autoimmune forms, remains controversial, especially in culturally conservative populations.
Samih Abed Odhaib, Mahmood Thamer Altemimi, Abbas Ali Mansour   +2 more
doaj   +1 more source