The Continuous Challenge of Diagnosing patients with Fabry disease in Argentina : Genotype, Experiences, Anecdotes, and New Learnings [PDF]
, 2015 The lysosomal storage disorder Fabry disease (FD) is caused by pathogenic mutations in the α-galactosidase A gene, localized in X chromosome. Deficient enzymatic activity of the product of this gene, the lysosomal hydrolase α-galactosidase A, leads to ...
Ceci, Romina +3 more
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Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes [PDF]
, 2016 We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez
Barona-Gomez, Francisco +7 more
core +1 more source
De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug. [PDF]
, 2018 Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene metabolites, limited information ...
Ghosh, Saikat Kumar B +17 more
core +3 more sources
Clinical DiabetologyOBJECTIVE: This retrospective study aimed to determine the prevalence of hypothyroidism in patients with type 2 diabetes (T2D) and analyze factors associated with its diagnosis, as well as its association with T2D-related complications.
Haider Ayad Alidrisi +9 more
doaj +1 more source
Terpene Specialized Metabolism inArabidopsis thaliana [PDF]
The Arabidopsis Book, 2011 Terpenes constitute the largest class of plant secondary (or specialized) metabolites, which are compounds of ecological function in plant defense or the attraction of beneficial organisms. Using biochemical and genetic approaches, nearly all Arabidopsis thaliana (Arabidopsis) enzymes of the core biosynthetic pathways producing the 5-carbon building ...
Dorothea, Tholl, Sungbeom, Lee
openaire +2 more sources
The grape phylloxera plague as a natural experiment: the upkeep of vineyards in Catalonia (Spain), 1858-1935 [PDF]
, 2010 We present a comparative analysis of the impact and outcome in Catalonia of the wine rush and crash unleashed by the spread of the Grape Phylloxera plague in Europe (1865-1890).
Badia Miró, Marc +3 more
core +2 more sources
Clinical DiabetologyOBJECTIVE: This study aimed to evaluate real-world effectiveness and safety of once-daily liraglutide (1.2 mg) as an add-on to oral antidiabetic drugs (OADs) and/or insulin, in type 2 diabetes (T2D) patients with obesity in Iraq. MATERIALS AND METHODS: A
Haider Ayad Alidrisi +3 more
doaj +1 more source
An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications
Molecules, 2022 Benzophenanthridines belong to the benzylisoquinolic alkaloids, representing one of the main groups of this class. These alkaloids include over 120 different compounds, mostly in plants from the Fumariaceae, Papaveraceae, and Rutaceae families, which ...
José Ignacio Laines-Hidalgo +3 more
doaj +1 more source
Metabolic syndrome and the immunological affair with the blood-brain barrier [PDF]
, 2015 Copyright © 2015 Mauro, De Rosa, Marelli-Berg and Solito. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
De Rosa, V +3 more
core +1 more source
Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2
eLife, 2019 Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing Streptomyces. Streptomyces species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has
Emma J Gehrke +13 more
doaj +1 more source