Results 51 to 60 of about 80,525 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Craniomandibular Disorders in Pregnant Women: An Epidemiological Survey

Journal of Functional Morphology and Kinesiology, 2020
Temporomandibular joint (TMJ) disorder has been reported to be 1.5 to two times more common in women than men. Such a gender-based difference could be attributed to behavioral, hormonal, anatomical, and psychological characteristics.
Grazia Fichera, Alessandro Polizzi, Simone Scapellato, Giuseppe Palazzo, Francesco Indelicato   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

How to improve the outcomes of surgically treated proximal humeral osteoporotic fractures? A narrative review

Orthopedic Reviews, 2020
Proximal humeral fractures (PHF) are the third most common non-vertebral fragility fractures after hip and distal radius. It still controversial which treatment might be more appropriate, and surgically treated outcomes depends also on an appropriate ...
Antonio Benedetto Cecere, Giuseppe Toro, Annalisa De Cicco, Adriano Braile, Marco Paoletta, Giovanni Iolascon, Alfredo Schiavone Panni   +6 more
doaj   +1 more source

Specialty Surgical Teams

AORN Journal, 1994
AORN Journal 59 (1994) 364-364.
Shands Hospital at the University of Florida Gainesville ( host institution ), RIDER, DOUG   +1 more
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Postgraduate Assessment Approaches across Surgical Specialties: A Systematic Review of the Published Evidence

, 2021
Purpose Ensuring competence for surgical trainees requires holistic assessment of the qualities and competencies necessary to practice safely and effectively.
Dedeilia, A., Papalois, A., Papalois, V., Sideris, M., Hanrahan, J.G., Pasha, T.   +5 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Internal hernia strangulated on appendicular tourniquet: a case report of an exceptional anomaly of the appendix revealed by a rare hernia

Surgical Case Reports, 2019
Background Internal hernias and the appendicular tourniquet are two rare pathologies. Case presentation We report here a case of a 68-year-old obese patient, who has acute small bowel obstruction due to strangulated internal hernia through an ...
Ismaïl Lawani, Cocou Yélinhan Patrice Houndje, Yacoubou Imorou Souaïbou, Dansou Gaspard Gbéssi, Setondji Gilles Roger Attolou, Freddy H. R. Gnangnon, Kouègnigan Sylvain Komadan, Houénoukpo Koco, Francis Moïse Dossou, Jean-Léon Olory-Togbé   +9 more
doaj   +1 more source