Results 91 to 100 of about 10,024,870 (318)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Updated extinction risk of seagrass species in the Tropical Atlantic Bioregion
Frontiers in Conservation ScienceSeagrasses can form vast meadows in coastal areas and provide valuable ecosystem services. Despite their importance, seagrasses are threatened, and their spatial extent and ecological condition have declined worldwide.
Jimena Samper-Villarreal +19 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
PlantsThe orchid Dendrobium moniliforme faces endangerment due to habitat loss and illegal harvesting, necessitating the development of an optimized artificial propagation system to aid conservation and reintroduction efforts.
Jung Eun Hwang +7 more
doaj +1 more source
Brakwaterpok - Amphibalanus improvisus. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]
, 2011 De oorspronkelijke herkomst van de brakwaterpok Amphibalanus improvisus is onduidelijk, waardoor de soort door veel wetenschappers als cryptogeen wordt aangeduid.
VLIZ Alien Species Consortium
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Rugstreepsteurgarnaal - Palaemon macrodactylus. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]
, 2011 Het oorspronkelijk verspreidingsgebied van de rugstreepsteurgarnaal Palaemon macrodactylus zijn de riviermondingen langs de kusten van Japan, China en Korea. Via transport in het ballastwater van schepen zou de soort naar Europa gekomen zijn.
VLIZ Alien Species Consortium
core
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source