Results 91 to 100 of about 10,139,462 (316)

The Origin of Species

Science, 1922
n ...
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genomic DNA barcodes provide novel insights into species delimitation in the complex Camellia sect. Thea (Theaceae)

BMC Plant Biology
Background Species delimitation within Camellia sect. Thea is taxonomically challenging due to its complex evolutionary history. This study aims to utilize nuclear and chloroplast data as genomic DNA barcodes to delimit species within this economically ...
Zongfang Shen, Yujing Feng, Michael Möller, Kevin S. Burgess, Hantao Qin, Junbo Yang, Zhiqiong Mo, Hongtao Li, Dezhu Li, Lianming Gao   +9 more
doaj   +1 more source

Influence of Basal Medium and Organic Additives on In Vitro Germination and Plant Growth of Endangered Orchid Gastrochilus fuscopunctatus

Plants
Gastrochilus fuscopunctatus is a rare epiphytic orchid in Korea threatened by habitat loss and illegal collection. This study aimed to establish an efficient in vitro propagation system by evaluating asymbiotic germination and seedling growth.
Jung Eun Hwang, Hyeong Bin Park, Jae-Hwa Tho, Myojin Kim, Hwan Joon Park, Seongjun Kim, Chang Woo Lee, Young-Joong Kim   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Drietakkig rooddonswier - Antithamnionella ternifolia. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]

, 2011
Het oorsprongsgebied van het drietakkig rooddonswier Antithamnionella ternifolia is eerder onduidelijk, hoewel er vermoedens zijn dat dit roodwier afkomstig is uit de zuidelijke hemisfeer. Dit niet-inheemse roodwier zou in Europese wateren terechtgekomen
VLIZ Alien Species Consortium
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Updated extinction risk of seagrass species in the Tropical Atlantic Bioregion

Frontiers in Conservation Science
Seagrasses can form vast meadows in coastal areas and provide valuable ecosystem services. Despite their importance, seagrasses are threatened, and their spatial extent and ecological condition have declined worldwide.
Jimena Samper-Villarreal, Jimena Samper-Villarreal, Joel C. Creed, Joel C. Creed, Duarte Frade, Duarte Frade, Bradley T. Furman, Bradley T. Furman, Salomão Bandeira, Salomão Bandeira, Hacen M. El-Hacen, Hacen M. El-Hacen, A. Carolina Peralta, A. Carolina Peralta, Ester A. Serrão, Ester A. Serrão, Beatriz E. Vera Vegas, Beatriz E. Vera Vegas, Brigitta I. van Tussenbroek, Brigitta I. van Tussenbroek   +19 more
doaj   +1 more source

Species on Digraphs

Advances in Mathematics, 1996
The author applies the language of Joyal's species to enumeration problems of digraphs using the machinery of coloured species, see, e.g., the author and \textit{O. Nava} [J. Comb. Theory, Ser. A 64, No. 1, 102-129 (1993; Zbl 0787.05095)]. A species over digraphs is defined as a functor from the category of digraphs to the category of finite sets and ...
openaire   +2 more sources