Results 71 to 80 of about 3,453,235 (267)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Classification of Seed Dormancy in Pedicularis hallaisanensis Hurusawa: An Endemic and Endangered Species Native to Korea

Horticulturae
Pedicularis hallaisanensis Hurusawa, native to Mt. Halla and Gaya, is an endangered endemic species. To support conservation efforts, this study investigated its germination characteristics and kind of seed dormancy. The seeds of P.
Hyeong-Bin Park, Jung Eun-Hwang, Dae Young-Jeon, Chang Woo-Lee, Hwan Joon-Park, Seongjun Kim, Young-Joong Kim, Young-Jun Yoon   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Genetic and Agromorphological Characterization of Sesame (Sesamum indicum L.) Genotypes for Dehiscence-Related Traits and Grain Yield Performances

International Journal of Agronomy
Sesame is of global economic, nutritional, and health importance. However, capsule dehiscence remains a major constraint in sesame production, causing significant yield losses.
Gazali B. T. A. Sanni, Vincent Ezin, Antoine Abel Missihoun, Quenum Florent, Adam Ahanchede   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Influence of Basal Medium and Organic Additives on In Vitro Germination and Plant Growth of Endangered Orchid Gastrochilus fuscopunctatus

Plants
Gastrochilus fuscopunctatus is a rare epiphytic orchid in Korea threatened by habitat loss and illegal collection. This study aimed to establish an efficient in vitro propagation system by evaluating asymbiotic germination and seedling growth.
Jung Eun Hwang, Hyeong Bin Park, Jae-Hwa Tho, Myojin Kim, Hwan Joon Park, Seongjun Kim, Chang Woo Lee, Young-Joong Kim   +7 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Genomic DNA barcodes provide novel insights into species delimitation in the complex Camellia sect. Thea (Theaceae)

BMC Plant Biology
Background Species delimitation within Camellia sect. Thea is taxonomically challenging due to its complex evolutionary history. This study aims to utilize nuclear and chloroplast data as genomic DNA barcodes to delimit species within this economically ...
Zongfang Shen, Yujing Feng, Michael Möller, Kevin S. Burgess, Hantao Qin, Junbo Yang, Zhiqiong Mo, Hongtao Li, Dezhu Li, Lianming Gao   +9 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source