Results 51 to 60 of about 10,024,870 (318)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Species highs [PDF]

Current Biology, 2009
SummaryA new report highlights the threat of climate change to new species discovered in the eastern Himalayas over recent years, writes Nigel Williams.
openaire   +2 more sources

Penseelkrab - Hemigrapsus takanoi. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]

, 2011
De penseelkrab Hemigrapsus takanoi kwam oorspronkelijk enkel voor in de Noordwest-Pacifische regio, maar werd via transportschepen - als larven in het ballastwater of in de aangroeilaag op de romp - naar Europa gebracht.
VLIZ Alien Species Consortium
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Proteome of seminal plasma and sperm associated with sperm survival following cryopreservation in the Red Wolf (Canis rufus)

Scientific Reports
Understanding of the impacts of seminal plasma and sperm proteins on both animal and human fertility has expanded rapidly in the last decade. However, little is known about the reproductive proteomes of endangered species. In this study, we characterized
Jasmin J. Celedon, Molly L. Corder, Meghann McConnell, Nucharin Songsasen, Jennifer B. Nagashima   +4 more
doaj   +1 more source

Zuiders waterezeltje - Proasellus coxalis. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]

, 2011
Het zuiders waterezeltje Proasellus coxalis is een zoetwaterpissebed, die oorspronkelijk enkel voorkwam in rivieren en riviermondingen rond het Middellandse Zeegebied.
VLIZ Alien Species Consortium
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Rood darmroeipootkreeftje - Mytilicola intestinalis. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]

, 2011
Het rood darmroeipootkreeftje Mytilicola intestinalis is een parasitair roeipootkreeftje dat zich in het spijsverteringsstelsel van mosselen nestelt. De soort kwam oorspronkelijk voor in de Middellandse Zee en is ongewild in onze streken terechtgekomen ...
VLIZ Alien Species Consortium
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source