Results 41 to 50 of about 10,139,462 (316)
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
【Objective】This research aimed to investigate the impacts of diets with different ratios of starch to cellulose on the growth, and physiological and biochemical indices of common carp (Cyprinus carpio). The findings were intended to provide a theoretical
Zhixin ZHANG +8 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Brede brakwaterpissebed - Synidotea laticauda. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]
De brede brakwaterpissebed Synidotea laticauda kwam oorspronkelijk enkel voor in ondiep brak water langs de westkust van de Verenigde Staten. Het is een omnivoor die vooral te vinden is op harde substraten zoals boeien, pontons en oesterbedden.
VLIZ Alien Species Consortium
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Applying the Key Biodiversity Area Standard to Important Sites for Sharks
The Kunming‐Montreal Global Biodiversity Framework commits nations to conserving 30% of coastal and marine areas, “especially areas of particular importance for biodiversity.” Key Biodiversity Areas (KBAs) provide a standardized approach for recognizing ...
Charlotte Boyd +7 more
doaj +1 more source
Japanse dansmug - Telmatogeton japonicus. Niet-inheemse soorten van het Belgisch deel van de Noordzee en aanpalende estuaria [PDF]
De Japanse dansmug Telmatogeton japonicus was oorspronkelijk enkel bekend van de Japanse kusten en Hawaï. Internationale scheepvaart is er waarschijnlijk voor verantwoordelijk dat deze soort zich heeft uitgebreid naar het Europese en het Atlantisch ...
VLIZ Alien Species Consortium
core
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source

