Results 51 to 60 of about 5,488,740 (248)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Invasive species threats and opportunities: a primer for Oregon policymakers

open access: yes, 2021
published by Oregon Invasive Species Council.Title from PDF cover (viewed on April 12, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Fish community studies from riverine Danube Delta (Romania) area in 2007: Şontea-Furtuna and Gorgova-Uzlina lake-complexes [PDF]

open access: yesScientific Annals of the Danube Delta Institute, 2009
The study of ichthyofauna from riverine delta, two lakes complexes Gorgova-Uzlina and Sontea- Furtuna was sampled in September 2007, using two complementary methods of sampling: electric fishing forshoreline and Nordic gillnet fishing for open water ...
NĂSTASE Aurel   +2 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Synthesis of Amylose−Polystyrene Inclusion Complexes by a Facile Preparation Route [PDF]

open access: yes, 2013
The formation of amylose−polystyrene inclusion complexes via a novel two-step approach is described. In the first-step, styrene was inserted inside the amylose helical cavity, followed by free radical polymerization in the second step.
Loos, Katja,   +6 more
core   +2 more sources

The Quest for Luminescent Iron Complexes

open access: yesPhotochem
The photochemistry of transition metal complexes has been crucial for the development of many fundamental topics, as well as to pave the way for several important applications.
Salvatore Genovese   +4 more
doaj   +1 more source

Protein complexes in bacteria.

open access: yesPLoS Computational Biology, 2015
Large-scale analyses of protein complexes have recently become available for Escherichia coli and Mycoplasma pneumoniae, yielding 443 and 116 heteromultimeric soluble protein complexes, respectively. We have coupled the results of these mass spectrometry-
J Harry Caufield   +3 more
doaj   +1 more source

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