Results 61 to 70 of about 5,488,740 (248)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
E-Journal of Chemistry, 2012 Cobalt(II), Nickel(II), Copper(II) and Manganese(II) complexes, having the general composition {M(L)2X2}, have been synthesized [where L= bis(pyridine-2-carbo) hydrazide(L), and X = Cl–].
Netra Pal Singh, Anu, Jagvir Singh
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New Jersey Strategic Management Plan for Invasive Species
, 2009 New Jersey has abundant biodiversity, natural resources and agricultural resources that are highly worth protecting for our citizens, both present and future.
core +1 more source
Fluoride, bifluoride and trifluoromethyl complexes of iridium(I) and rhodium(I) [PDF]
, 2015 The ERC (Advanced Researcher Award FUNCAT to SPN), the EPSRC and Sasol (Stipend to BJT) are gratefully acknowledged for support.Herein we report robust methods for the preparation and full characterisation of a range of Ir(I) and Rh(I) fluoride and ...
Slawin, Alexandra MZ +8 more
core +1 more source
Infection and Drug Resistance, 2020 Sujiraphong Pharkjaksu, 1 Piriyaporn Chongtrakool, 1 Methee Chayakulkeeree, 2 Chalermchai Mitrpant, 3 Pornpimon Angkasekwinai, 4 John E Bennett, 5 Kyung J Kwon-Chung, 5 Popchai Ngamskulrungroj 1 1Department of Microbiology, Faculty of Medicine Siriraj ...
Pharkjaksu S +7 more
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Metal complexes as DNA intercalators [PDF]
, 2011 DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler +3 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source