Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Review of Campsicnemus species from the Atlantic Ocean Islands (Diptera: Dolichopodidae) [PDF]
New species Campsicnemus flavissimus sp. nov., C. meridionalis sp. nov., and C. sanctaehelenae sp. nov. are described from St. Helena. A review and key to seven Campsicnemus species inhabiting Azores, Canary Is., Madeira and St. Helena are provided.
Igor Grichanov +2 more
core +1 more source
Plant–herbivore–parasitoid systems are poorly studied in the tropics. Enicospilus carmenae Campos and Palacio sp. nov. are described, originating from southern Mexico in the Yucatan Peninsula and establishing a new tri-trophic interaction.
Diego Fernando Campos-Moreno +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Characterization of Iberian species of the genus Pungentus Thorne & Swanger, 1936 (Nematoda, Dorylaimida, Nordiidae) [PDF]
Several populations of four known species of the genus Pungentus (P. clavatus, P. engadinensis, P. marietani and P. silvestris), collected in the wild and in cultivated soils from the Iberian Peninsula, are studied.
Ciobanu, Marcel +6 more
core +1 more source
DESCRIPTION OF A NEW SPECIES OF COPÆODES [PDF]
Copæodes Wrighth.Male.—Expands .9 inch.Upper side yellow-ochre color; costal margin of primaries black on the edge, and hind margins of both wings edged black, scarcely more than a line; costal margin of secondaries broadly bordered black; the ends of the nervules on primaries edged black for a little distance; on the disk a black sexual narrow bar ...
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Use of the Genealogical Sorting Index (GSI) to delineate species boundaries in the Neofusicoccum parvum-Neofusicoccum ribis species complex [PDF]
Neofusicoccum is a recently described genus of common endophytes and pathogens of woody hosts, previously placed in the genus Botryosphaeria. Many morphological characteristics routinely used to describe species overlap in Neofusicoccum, and prior to the
Hardy, G.E.St.J. +2 more
core
DESCRIPTION OF A NEW SPECIES OF OLIVA [PDF]
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

