Results 101 to 110 of about 207,823 (255)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Historical Demography and Climate Driven Range Shifts in the Blue-spotted Salamander Under the Climate Change Scenarios

European Journal of Ecology
This study integrates phylogeography with distributional analysis to understand the demographic history and range dynamics of a limited dispersal capacity amphibian species, Blue-spotted Salamander (Ambystoma laterale), under several climate change ...
UTKU PERKTAS, Can Elverici, Özge Yaylalı   +2 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Lumping and Splitting of Distribution Models Across a Biogeographic Divide Informs the Conservation of an Imperiled Fluvial Fish

Ecology and Evolution
Freshwater fishes are among the most threatened taxa in the world. A major challenge for the conservation and management of threatened fishes is scarce information regarding life history, habitat requirements, and the drivers of declines.
Briant D. Nguyen, Jenna Messick, Anthony W. Rodger, Victoria Jackson, Christopher Butler, Andrew T. Taylor   +5 more
doaj   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Ecological Modeling of the Potential Distribution of the Mistletoe Phoradendron nervosum (Viscaceae) Parasitism in Ecuador

Agriculture
This study characterizes Phoradendron nervosum, a hemiparasitic mistletoe species prevalent in Ecuador, using morphological, molecular, and ecological modeling approaches. Morphological analysis revealed that P.
Daniela Chavez, Nancy Nénger, Carlos Bolaños-Carriel, Jorge Espinosa Marín, Wellington Bastidas, Ligia García   +5 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Prediction of geographic distribution and ecological niche modeling of açaí palm trees in the Amazon

Pesquisa Agropecuária Tropical
Euterpe precatoria Mart. (açaí-do-amazonas) and Euterpe oleracea Mart. (açaí-do-pará) are palm trees of socioeconomic importance to Brazil, and fruit demand has increased due to its nutritional characteristics.
Maria José Marques, Caroline de Souza Bezerra, Jennifer Souza Tomaz, Ricardo Lopes, Marcos Silveira Wrege, Ananda Virginia de Aguiar, Santiago Linorio Ferreyra Ramos, Carlos Henrique Salvino Gadêlha Meneses, Therezinha de Jesus Pinto Fraxe, Maria Teresa Gomes Lopes   +9 more
doaj   +1 more source

Trends in mosquito species distribution modeling: insights for vector surveillance and disease control. [PDF]

Parasit Vectors, 2023
Lippi CA, Mundis SJ, Sippy R, Flenniken JM, Chaudhary A, Hecht G, Carlson CJ, Ryan SJ.   +7 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source