Results 111 to 120 of about 3,676,569 (297)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Evaluating presence‐only species distribution models with discrimination accuracy is uninformative for many applications

Journal of Biogeography, 2019
Species distribution models are used across evolution, ecology, conservation and epidemiology to make critical decisions and study biological phenomena, often in cases where experimental approaches are intractable.
D. Warren, N. Matzke, T. Iglesias
semanticscholar   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

An evaluation of stringent filtering to improve species distribution models from citizen science data

Diversity and Distributions: A journal of biological invasions and biodiversity, 2019
Citizen science data are increasingly used for modelling species distributions because they offer broad spatiotemporal coverage of local observations. However, such data are often collected without experimental design or set survey methods, raising the ...
V. Steen, C. Elphick, M. Tingley
semanticscholar   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Modelling species distribution at the boundaries of the Earth's climate

Global Ecology and Biogeography
11institutetext: Knowledge-based Systems and Document Processing Research Group Faculty of Computer Science Otto-von-Guericke-University Magdeburg 11email: katrin.krieger@ovgu.de Correlative species distribution models (SDMs) are widely used to project the responses of biodiversity to global changes.
Serafini C., Cosentino F., Amori G., Maiorano L.   +3 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Species-free species distribution models describe macroecological properties of protected area networks.

PLoS ONE, 2017
Among the greatest challenges facing the conservation of plants and animal species in protected areas are threats from a rapidly changing climate. An altered climate creates both challenges and opportunities for improving the management of protected ...
Jason L Robinson, James A Fordyce
doaj   +1 more source

Spatially explicit species distribution models: A missed opportunity in conservation planning?

Diversity and Distributions: A journal of biological invasions and biodiversity, 2019
Systematic conservation planning is vital for allocating protected areas given the spatial distribution of conservation features, such as species. Due to incomplete species inventories, species distribution models (SDMs) are often used for predicting ...
S. Domisch, Martin Friedrichs, Thomas Hein, F. Borgwardt, Annett Wetzig, S. Jähnig, S. Langhans   +6 more
semanticscholar   +1 more source