Results 141 to 150 of about 4,765,745 (329)

Spatially explicit species distribution models: A missed opportunity in conservation planning?

open access: yesDiversity and Distributions: A journal of biological invasions and biodiversity, 2019
Systematic conservation planning is vital for allocating protected areas given the spatial distribution of conservation features, such as species. Due to incomplete species inventories, species distribution models (SDMs) are often used for predicting ...
S. Domisch   +6 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Species-free species distribution models describe macroecological properties of protected area networks.

open access: yesPLoS ONE, 2017
Among the greatest challenges facing the conservation of plants and animal species in protected areas are threats from a rapidly changing climate. An altered climate creates both challenges and opportunities for improving the management of protected ...
Jason L Robinson, James A Fordyce
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

TTR.PGM: An R package for modelling the distributions and dynamics of plants using the Thornley transport resistance plant growth model

open access: yesMethods in Ecology and Evolution
An ability to predict the ranges and dynamics of species is central to ecological and evolutionary research. Despite species range modelling being an active area of research for the past three to four decades, methods for predicting species ranges and ...
Steven I. Higgins   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Integrating Dynamic Subsurface Habitat Metrics Into Species Distribution Models

open access: yesFrontiers in Marine Science, 2018
Species distribution models (SDMs) have become key tools for describing and predicting species habitats. In the marine domain, environmental data used in modeling species distributions are often remotely sensed, and as such have limited capacity for ...
Stephanie Brodie   +17 more
doaj   +1 more source

Macro-evolutionary models and coalescent point processes: The shape and probability of reconstructed phylogenies

open access: yes, 2013
Forward-time models of diversification (i.e., speciation and extinction) produce phylogenetic trees that grow "vertically" as time goes by. Pruning the extinct lineages out of such trees leads to natural models for reconstructed trees (i.e., phylogenies ...
Lambert, Amaury, Stadler, Tanja
core  

Modelling biodiversity scenarios in madagascar under both the effects of climate change and anthropogenic deforestation [PDF]

open access: yes, 2015
Madagascar is widely known for its exceptional biodiversity which is, for the terrestrial part, mainly concentrated in tropical forests. This biodiversity is severely threatened by both climate change and deforestation.
Allnutt, Thomas F.   +7 more
core  

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