Results 171 to 180 of about 1,152,264 (269)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

From Species Identification to Empirical Therapy: A Machine Learning and Rule-Based Decision Support Framework for Antifungal Resistance Prediction in ICU <i>Candida</i> Infections. [PDF]

Med Sci (Basel)
Solomon MP, Mahler B, Ditu LM, Popescu O, Zugravu CA, Manolescu LSC.   +5 more
europepmc   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Evaluation of the GenoType Mycobacterium CM/AS Assay for Species Identification of Mycobacteria. [PDF]

Cureus
Ramudamu M, Malhotra B.
europepmc   +1 more source

Correction to "3RAD-Guided SNP Discovery for Species Identification and Conservation of the Medicinal Southern African Tree Genus <i>Greyia</i> Hook. & Harv." [PDF]

Ecol Evol
europepmc   +1 more source

Rapid on-site universal vertebrate species identification via multi-barcode nanopore sequencing. [PDF]

PLoS One
Patterson EC, Morrison-Lanjouw S, Jobling MA, Wetton JH.   +3 more
europepmc   +1 more source

Adaptive Observer for Coupled Wave PDE and Infinite ODE With Sampled Data and Unknown Input: Application to Brain Hemodynamics Estimation

International Journal of Adaptive Control and Signal Processing, EarlyView.
This article proposes a convergent adaptive observer for a damped wave PDE and an infinite‐dimensional ODE coupled in cascade using sampled‐in‐space ODE state measurements. The proposed observer estimates the distributed states of the PDE and ODE along with unknown PDE parameters and spatial input.
Zehor Belkhatir, Sarah Mechhoud, Taous‐Meriem Laleg‐Kirati   +2 more
wiley   +1 more source

A Preliminary Study on Species Identification of Immature Necrophagous Phorid Flies Based on FTIR Spectroscopy. [PDF]

Animals (Basel)
Jia W, Feng D, Tang Y.
europepmc   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Deep learning based optimal fish species identification to maximize production in fish ponds. [PDF]

Sci Rep
Arabelli R, Bernatin T, Veeramsetty V, Basha CHH.   +3 more
europepmc   +1 more source