Results 81 to 90 of about 354,259 (294)
Distribution patterns of dinoflagellate communities along the Songhua River [PDF]
PeerJ, 2019 Background Dinoflagellates have the potential to pose severe ecological and economic damages to aquatic ecosystems. It is therefore largely needed to understand the causes and consequences of distribution patterns of dinoflagellate communities in order ...
Yangchun Gao +4 more
doaj +2 more sources
Species sorting drives variation of boreal lake and river macrophyte communities [PDF]
Community Ecology, 2015 Metacommunity paradigms are increasingly studied to explain how environmental control and spatial patterns determine variation in community composition. However, the relative importance of these patterns on biological assemblages among different habitats is not well known.
Alahuhta, J. +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Parasites & Vectors, 2018 Background Several mosquito population suppression strategies based on the rearing and release of sterile males have provided promising results. However, the lack of an efficient male selection method has hampered the expansion of these approaches into ...
Mario Zacarés +7 more
doaj +1 more source
Intramitochondrial sorting of the precursor to yeast cytochrome c oxidase subunit Va. [PDF]
, 1993 We have continued our studies on the import pathway of the precursor to yeast cytochrome c oxidase subunit Va (pVa), a mitochondrial inner membrane protein.
Cumsky, MG, Miller, BR
core
Membrane-associated proteins in giardia lamblia [PDF]
, 2018 The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Beta diversity among prairie restorations increases with species pool size, but not through enhanced species sorting [PDF]
Journal of Ecology, 2014 SummaryUnderstanding variation in community composition across space, or beta diversity, is of longstanding interest in ecology, yet the determinants of beta diversity remain poorly known. In part, this results from a lack of manipulative tests of hypothesized drivers.
Emily Grman, Lars A. Brudvig
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source