Results 111 to 120 of about 5,670,475 (303)

Tissue-specific and species-specific esterases [PDF]

Biochemical Journal, 1961
J, PAUL, P, FOTTRELL
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patterns of interaction specificity of fungus-growing termites and Termitomyces symbionts in South Africa

BMC Evolutionary Biology, 2007
Background Termites of the subfamily Macrotermitinae live in a mutualistic symbiosis with basidiomycete fungi of the genus Termitomyces. Here, we explored interaction specificity in fungus-growing termites using samples from 101 colonies in South-Africa ...
de Beer Z Wilhelm, Mitchell Jannette, de Fine Licht Henrik H, Ros Vera ID, Aanen Duur K, Slippers Bernard, Rouland-LeFèvre Corinne, Boomsma Jacobus J   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids. [PDF]

Molecules, 2023
Borio A, Holgado A, Passegger C, Strobl H, Beyaert R, Heine H, Zamyatina A.   +6 more
europepmc   +1 more source

Mollicute and other bacterial species used for testing analytical specificity of the multiplex probe PCR assay.

, 2017
Mollicute and other bacterial species used for testing analytical specificity of the multiplex probe PCR assay.
Katrina L. Bosward (845321), Mark S. Hazelton (3815779), Paul A. Sheehy (3815776), Alysia M. Parker (3815773), John K. House (171521)   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens

Cell Reports Medicine
Summary: Therapeutic antibodies are actively explored as alternative to treat or prevent bacterial infections. However, the narrow antigen specificity of IgG in combination with broad diversity in bacterial surface structures currently hampers the ...
Remy M. Muts, Astrid Hendriks, Josefien W. Hommes, Max L.B. Grönloh, Douwe J. Dijkstra, Carla J.C. de Haas, Piet C. Aerts, Eduard H.T.M. Ebberink, Albert J.R. Heck, Zhen Wang, Haoru Zhuang, Jeroen D.C. Codée, Bas G.J. Surewaard, Dani A.C. Heesterbeek, Nina M. van Sorge, Suzan H.M. Rooijakkers   +15 more
doaj   +1 more source

Mating pair stabilization mediates bacterial conjugation species specificity. [PDF]

Nat Microbiol, 2022
Low WW, Wong JLC, Beltran LC, Seddon C, David S, Kwong HS, Bizeau T, Wang F, Peña A, Costa TRD, Pham B, Chen M, Egelman EH, Beis K, Frankel G.   +14 more
europepmc   +1 more source