Results 111 to 120 of about 5,443,598 (303)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Assessing host-parasite specificity through coprological analysis: A case study with species of Corynosoma (Acanthocephala: Polymorphidae) from marine mammals [PDF]

, 2012
In this paper we report an investigation of the utility of coprological analysis as an alternative technique to study parasite specificity whenever host sampling is problematic; acanthocephalans from marine mammals were used as a model.
García Varela, M., Aznar Avendaño, Francisco Javier, Suarez, Amalia Andrea, Raga, J. A., Hernández Orts, Jesús Servando, Cappozzo, Humberto Luis   +5 more
core   +1 more source

Sequence similarity is more relevant than species specificity in probabilistic backtranslation

BMC Bioinformatics, 2007
Background Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module.
Di Pietro Cinzia, Pulvirenti Alfredo, Pigola Giuseppe, Giugno Rosalba, Ferro Alfredo, Purrello Michele, Ragusa Marco   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids. [PDF]

Molecules, 2023
Borio A, Holgado A, Passegger C, Strobl H, Beyaert R, Heine H, Zamyatina A.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Specificity and Economic Performance [PDF]

, 2014
2014-12Long-term business relationships with specific investments prevail extensively in transactions of intermediate goods, while economic theories have traditionally presumed market transactions. But relation-specific production is also known to have a
Minagawa, Tadashi, Yoneda, Koji
core  

Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens

Cell Reports Medicine
Summary: Therapeutic antibodies are actively explored as alternative to treat or prevent bacterial infections. However, the narrow antigen specificity of IgG in combination with broad diversity in bacterial surface structures currently hampers the ...
Remy M. Muts, Astrid Hendriks, Josefien W. Hommes, Max L.B. Grönloh, Douwe J. Dijkstra, Carla J.C. de Haas, Piet C. Aerts, Eduard H.T.M. Ebberink, Albert J.R. Heck, Zhen Wang, Haoru Zhuang, Jeroen D.C. Codée, Bas G.J. Surewaard, Dani A.C. Heesterbeek, Nina M. van Sorge, Suzan H.M. Rooijakkers   +15 more
doaj   +1 more source

Mating pair stabilization mediates bacterial conjugation species specificity. [PDF]

Nat Microbiol, 2022
Low WW, Wong JLC, Beltran LC, Seddon C, David S, Kwong HS, Bizeau T, Wang F, Peña A, Costa TRD, Pham B, Chen M, Egelman EH, Beis K, Frankel G.   +14 more
europepmc   +1 more source