Results 161 to 170 of about 1,256,681 (354)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Airborne HCl - CO sensing system [PDF]

open access: yes
A system for measuring air pollutants in-situ using an aircraft was designed, fabricated, and tested. The system is based upon a technique called Gas Filter Correlation (GFC) which provides for high sensitivity and specificity in the presence of ...
Bartle, E. R., Hall, G.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Odour perception in the codling moth Cydia pomonella L. [PDF]

open access: yes, 2004
The codling moth, Cydia pomonella L. (Lepidoptera: Tortricidae) is a renowned pest in apple, pear and walnut orchards, and its activities are in large guided by volatile odours as sensory cues.
Ansebo, Lena
core  

Gonad Differentiation in the Rabbit: Evidence of Species-Specific Features

open access: gold, 2013
Nathalie Daniel   +5 more
openalex   +2 more sources

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