Results 301 to 310 of about 1,256,681 (354)

Towards Species-specific Antifolates

Current Medicinal Chemistry, 2006
Dihydrofolate reductase (DHFR) plays an essential role in cellular biochemistry and has been a well-recognized drug target for over fifty years. Antifolate inhibitors of DHFR, including clinically used therapeutics such as methotrexate, trimethoprim, and pyrimethamine have been successful as anticancer, antibacterial, antifungal and antiparasitic ...
D C M, Chan, A C, Anderson
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Species specificity of streptokinase

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1983
Streptokinase, a bacterial protein, forms a complex with human plasminogen which results in a conformational change in the plasminogen molecule and the exposure of an active center. The plasminogen-streptokinase complex is an activator of plasminogen and is rapidly converted to a plasmin-streptokinase complex which, in the human, is also an activator ...
J A, Marcum, D L, Kline
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Species specificity of informatin

Molecular Biology Reports, 1977
Informatin, the protein moiety of nuclear pre-mRNA containing particles, exhibits species specific antigenic properties but shows also some interspecies cross-reactivities.
F, Noll, E M, Lukanidin
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Species-Specific Myoglobin Oxidation

Journal of Agricultural and Food Chemistry, 2011
The effect of the lipid oxidation product, 4-hydroxy-2-nonenal (HNE), on oxidation of oxymyoglobin (OxyMb) from seven different meat-producing species was investigated. Relative to controls, HNE increased OxyMb oxidation within all species (p < 0.05) at both 25 and 4 °C, pH 5.6. The relative effect of HNE was greater for myoglobins (Mbs) that contained
Shuang, Yin, Cameron, Faustman, Nantawat, Tatiyaborworntham, Ranjith, Ramanathan, Naveena B, Maheswarappa, Richard A, Mancini, Poulson, Joseph, Surendranath P, Suman, Qun, Sun   +8 more
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Species-specific and Non-species-specific Elemental Trends in Tree Rings

Doklady Earth Sciences, 2021
The goal was to find out how consistent the elemental distributions in tree rings are. The dataset was received for a long-term afforestation experiment that included even soil conditions and a variety of conifers (Scots pine, Norway spruce, Siberian pine, and Siberian larch) growing in pure stands.
V. L. Gavrikov, A. I. Fertikov, R. A. Sharafutdinov, E. A. Vaganov   +3 more
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Species Specificity of Tissue Thromboplastin

Pathophysiology of Haemostasis and Thrombosis, 1984
The species specificity of thromboplastin (tissue factor) is an important fact to take into consideration when clotting assays or experiments are planned. We have (re)investigated all possible combinations of thromboplastin and plasma from several of the most commonly used species of experimental animals.
T L, Janson, H, Stormorken, H, Prydz
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Species specificity in protein synthesis

Journal of Molecular Biology, 1967
The phenomenon of species specificity in poly U-directed cell-free protein synthesis (whereby combinations of ribosomes of one organism with supernatant enzymes from a different one are sometimes inactive) was studied in the case of the amino acid-incorporating systems prepared from Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae ...
B, Parisi, G, Milanesi, J L, Van Etten, A, Perani, O, Ciferri   +4 more
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Histones: Species and Tissue Specificity

Science, 1964
Within a given species (rat, mouse, guinea pig, rabbit) the histones of brain, liver, and kidney are indistinguishable on disc electrophoresis in polyacrylamide gels. However, characteristic species differences were observed. In the immature rat, the histones of brain and liver, while very similar to each other, differ from those of the adult.
A, NEIDLE, H, WAELSCH
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Are oestrus odours species specific?

Behavioural Brain Research, 2006
Adult male rats were exposed to faeces odours of three animal species (rat, fox and horse). They displayed erections in the presence of faeces from oestrous females (whatever the species). In addition, fox faeces (whatever the gender or hormonal status) elicited an expected freezing reaction.
Rampin, Olivier, Jerome, Nathalie, Briant, Christine, Boué, Franck, Maurin, Yves   +4 more
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Species-specific mechanisms during fertilization

2020
The perpetuation and preservation of distinct species rely on mechanisms that ensure that only interactions between gametes of the same species can give rise to viable and fertile offspring. Species-specificity can act at various stages, ranging from physical/behavioral pre-copulatory mechanisms, to pre-zygotic incompatibility during fertilization, to ...
Krista R, Gert, Andrea, Pauli
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