Results 51 to 60 of about 637,679 (310)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Competition of Species with Intra-Specific Competition [PDF]
Mathematical Modelling of Natural Phenomena, 2008 Intra-specific competition in population dynamics can be described by integro-differen- tial equations where the integral term corresponds to nonlocal consumption of resources by in- dividuals of the same population. Already the single integro-differential equation can show the emergence of nonhomogeneous in space stationary structures and can be used ...
Apreutesei, Narcisa +2 more
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Species-specific temperature sensitivity of TRPA1 [PDF]
Temperature, 2015 Transient receptor potential ankyrin 1 (TRPA1) is a polymodal ion channel sensitive to temperature and chemical stimuli. The importance of temperature and aversive chemical detection for survival has driven the evolutionary diversity of TRPA1 sensitivity.
Willem J. Laursen +4 more
openaire +3 more sources
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Frontiers in Pharmacology, 2014 One approach to experimental science involves creating hypotheses, then testing them by varying one or more independent variables and assessing the effects of this variation on the processes of interest.
Douglas Bruce Kell +1 more
doaj +1 more source
Software for the Analysis of Species-Specific Vocalizations [PDF]
Acta Medica (Hradec Kralove, Czech Republic), 2004 Vocalization calls are behaviorally relevant complex sounds that typically contain several harmonics and show frequency and amplitude modulation. In this paper, an introduction to a software tool for the analysis of species-specific vocalizations is presented.
Martin Komárek +3 more
openaire +4 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Substrate specificity of glucokinase and fructokinase of several conifer species
Acta Societatis Botanicorum Poloniae, 2014 Annual plant species were found to have several distinct classes of hexokinases which are specific for different hexoses, such as glucose, fructose and mannose.
Fritz Bergmanni, Leon Mejnartowicz
doaj +1 more source