Results 71 to 80 of about 5,443,598 (303)

Species-Specificity in Myoglobin Oxygenation and Reduction Potential Properties

Meat and Muscle Biology, 2017
The objective was to compare oxygenation and reduction potential properties of bovine and porcine myoglobins in-vitro. Cyclic voltammetry and homology-based myoglobin modeling were used to determine the species-specific effects on myoglobin reduction ...
Rajasekhara Nerimetla, Sadagopan Krishnan, Suman Mazumder, Smita Mohanty, Gretchen G. Mafi, Deborah L. VanOverbeke, Ranjith Ramanathan   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

THE BASIC FUNCTIONS OF SOUND SIGNALS IN MAMMALS

RUDN Journal of Ecology and Life Safety, 2016
All the diversity of sound signals by mammals is subordinated two basic functions: function implementation of the populations of genotype and function realization of the ecological niche of species populations. The basic functions have resulted from some
A A Nikol’skii
doaj  

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Frontiers in Pharmacology, 2014
One approach to experimental science involves creating hypotheses, then testing them by varying one or more independent variables and assessing the effects of this variation on the processes of interest.
Douglas Bruce Kell, Stephen George Oliver   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Invasive Species Definition Clarification and Guidance White Paper

, 2006
Paper discussing a "a non-regulatory policy interpretation of the term invasive species" through a positional defintion of what and what does not constittue an invasive species along with examples of impacts caused by invasive species.
Definitions Subcommittee of the Invasive Species Adivsory Committee
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

2008 - 2012 National Invasive Species Management Plan [PDF]

, 2008
Document outlining recommendations, roles and responsibilities, and other components of the plan/strategy intended to prevent, control, and minimize invasive species and their impact in the United States from 2008 to ...
National Invasive Species Council (U.S.)
core  

Female-induced increase of host-plant volatiles enhance specific attraction of aphid male Dysaphis plantaginea (Homoptera: Aphididae) to the sex pheromone [PDF]

, 2009
All aphid species studied so far share the same sex pheromone components, nepetalactol and nepetalactone. Variation by different enantiomers and blends of the two components released by different aphid species are limited and can only partially explain ...
Tol, R.W.H.M., van, Helsen, H.H.M., Griepink, F.C., Kogel, W.J., de   +3 more
core   +1 more source

Species differences influencing the safety assessment of CD3 T-cell engagers

Journal of Immunotoxicology
Bispecific CD3 T-cell engagers (TCE) redirect endogenous T-cells to tumor cells and have demonstrated substantial clinical activity, but their mechanism of action also drives immune-mediated toxicities that are often underpredicted in nonhuman primate ...
Taylor L Hickman, David A Gallegos, Shihui Zhong, Lauren Gauthier, Matthew P Wagoner, Mansoor M. Amiji   +5 more
doaj   +1 more source