Results 81 to 90 of about 744,887 (310)

Species-Specificity in Myoglobin Oxygenation and Reduction Potential Properties

Meat and Muscle Biology, 2017
The objective was to compare oxygenation and reduction potential properties of bovine and porcine myoglobins in-vitro. Cyclic voltammetry and homology-based myoglobin modeling were used to determine the species-specific effects on myoglobin reduction ...
Rajasekhara Nerimetla, Sadagopan Krishnan, Suman Mazumder, Smita Mohanty, Gretchen G. Mafi, Deborah L. VanOverbeke, Ranjith Ramanathan   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Frontiers in Pharmacology, 2014
One approach to experimental science involves creating hypotheses, then testing them by varying one or more independent variables and assessing the effects of this variation on the processes of interest.
Douglas Bruce Kell, Stephen George Oliver   +1 more
doaj   +1 more source

Species variation in Rubisco specificity factor

, 1995
Ribulose-1, 5-bisphosphate carboxylase/oxygenase(Rubisco) was highly purified from nine species native to the Balearic Islands. The specificity factor for Rubisco from each species was determined and compared with that of wheat.
Medrano, H., Parry, M. A. J., Parry, M. A., Delgado, E., Keys, A. J.   +4 more
core  

SPR analysis and species-specificity of bevacizumab.

, 2016
(A) SPR sensorgram and kinetic constants of bevacizumab for human VEGF. (B) Species-specificity of bevacizumab against mouse VEGF by ELISA.
Jong Rok Oh (2576902), Da-Eun Hwang (2576893), Jung Woo Han (388397), Tae Kwann Park (2576899), Jeong-Hyun Ryou (2576896), Hak-Sung Kim (182795)   +5 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Editorial: History of Growth Hormone: Animal to Human

Frontiers in Endocrinology, 2021
Edward O. Reiter, Laurie E. Cohen, Alan D. Rogol   +2 more
doaj   +1 more source

Species differences influencing the safety assessment of CD3 T-cell engagers

Journal of Immunotoxicology
Bispecific CD3 T-cell engagers (TCE) redirect endogenous T-cells to tumor cells and have demonstrated substantial clinical activity, but their mechanism of action also drives immune-mediated toxicities that are often underpredicted in nonhuman primate ...
Taylor L Hickman, David A Gallegos, Shihui Zhong, Lauren Gauthier, Matthew P Wagoner, Mansoor M. Amiji   +5 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source