Results 81 to 90 of about 7,231,771 (330)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The Shapley Value of Phylogenetic Trees [PDF]

open access: yes, 2007
Every weighted tree corresponds naturally to a cooperative game that we call a "tree game"; it assigns to each subset of leaves the sum of the weights of the minimal subtree spanned by those leaves.
Haake, Claus-Jochen   +2 more
core   +3 more sources

Gene tree correction for reconciliation and species tree inference [PDF]

open access: yesAlgorithms for Molecular Biology, 2012
Reconciliation is the commonly used method for inferring the evolutionary scenario for a gene family. It consists in "embedding" inferred gene trees into a known species tree, revealing the evolution of the gene family by duplications and losses. When a species tree is not known, a natural algorithmic problem is to infer a species tree from a set of ...
Swenson Krister M   +2 more
openaire   +3 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Evolution of Plant AIG1-like Proteins: Different Modes of Sequence Divergence and Their Contributions to Functional Diversification

open access: yesPlants
AIG1 (avrRpt2-induced gene 1)-like proteins are a class of GTPases that play crucial roles in plants, functioning both in chloroplast protein import and disease resistance.
Jiajing Peng   +3 more
doaj   +1 more source

Appropriate Assignment of Fossil Calibration Information Minimizes the Difference between Phylogenetic and Pedigree Mutation Rates in Humans

open access: yesLife, 2018
Studies that measured mutation rates in human populations using pedigrees have reported values that differ significantly from rates estimated from the phylogenetic comparison of humans and chimpanzees. Consequently, exchanges between mutation rate values
Renata T. Capellão   +2 more
doaj   +1 more source

Convergent Morphological Evolution in Silene Sect. Italicae (Caryophyllaceae) in the Mediterranean Basin

open access: yesFrontiers in Plant Science, 2022
Recent divergence can obscure species boundaries among closely related taxa. Silene section Italicae (Caryophyllaceae) has been taxonomically controversial, with about 30 species described.
Yamama Naciri   +11 more
doaj   +1 more source

Fungal community survey of Fraxinus excelior in New Zealand [PDF]

open access: yes, 2012
The European Ash tree (Fraxinus excelsior) is widely grown throughout Europe. As a large deciduous tree species, it grows a tall, domed crown and has an attractive tree shape, so it is considered as a popular amenity tree species. European Ash is planted
Chen, Jie
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Tree species effect on natural control of H. albipunctella de Joannis in a millet agroforestry system in Senegal [PDF]

open access: yes, 2019
Association of several tree species in and around a plot can have a positive impact on ecosystem services. Thus, traditional agroforestry systems, characterized by a high plant diversity, constitute an ideal model of study to test if the natural tree ...
Brévault, Thierry   +4 more
core  

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