Results 31 to 40 of about 684 (253)

Astrobiology and Astrophilosophy: Subsuming or Bifurcating Disciplines? [PDF]

Философия и космология, 2019
Initially, astrobiology subsumed into philosophy. However, philosophy has increasingly subsumed into astrobiology concurrent with it steadily becoming an observational and experimental activity that mainly focuses on the link between life and the ...
Ian von Hegner
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Peter Singer’s Speciesist Notion of Animal Conservation Vis-a-Vis Genetic Manipulation

Studia Ecologiae et Bioethicae
This paper shows how human activity through genetic engineering causes pain to non-human animals. It primarily deals with an evaluation of the phenomenon of animal rights (specifically animal conservation) from the view of Singer’s notion of speciesism.
Gabriel Bubu Ncha, Emmanuel E. Etta, Lawrence Odey Ojong   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

If Natural Entities Have Intrinsic Value, Should We Then Abstain from Helping Animals Who Are Victims of Natural Processes?

Relations, 2015
The idyllic view of nature is false: natural processes, given the prevalence of the reproductive strategy known as “r-selection”, tend to maximize the suffering of animals in nature. For the animals subjected to natural processes, disvalue overwhelmingly
Luciano Carlos Cunha
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Starry white trek: Science fiction and racial discourse [PDF]

Sociološki Pregled, 2012
This article demonstrates that the science fiction’s visions of the future are not exempt from problems of rasism even when openly opposed it. Film and TV Star Trek production is commonly regarded as a significant example of courageous and effective ...
Krstić Predrag
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dialectical Materialism or Dialectics of the Human?: Marxism and Animal Liberation Movement

Uluslararası Halkbilimi Araştırmaları Dergisi
With reference to the book “18 Theses on Marxism and Animal Liberation”, published by the Alliance for Marxism and Animal Liberation, which aims to create a point of consensus between Marxism and the anti-speciesism struggle, this article discusses the ...
Erhan Korkmaz
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source