Results 71 to 80 of about 672 (250)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Le World Wild Web et l’animalisme radical

open access: yesIm@go. A Journal of the Social Imaginary, 2016
After a first escalation on the nineteenth century, animal liberation phenomenon knows an hermeneutics rehabilitation through the web network development. Thanks to the virality of electronic channels, many people are being connected to animalism warfare
Marianne Celka
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

“Meat-me”: From flesh machines to individualities. A case for an anti-speciesist degrowth

open access: yesJournal of Political Ecology
Degrowth, a leading paradigm addressing our socio-ecological crisis, criticizes the highly destructive animal factory-farming industry. However, it does not challenge the commodification of sentient beings and the underlying system that perpetuates the ...
Eva Navarro
doaj   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Anti Robot Speciesism

open access: yesCoRR
Humanoid robots are a form of embodied artificial intelligence (AI) that looks and acts more and more like humans. Powered by generative AI and advances in robotics, humanoid robots can speak and interact with humans rather naturally but are still easily recognizable as robots.
Julian De Freitas   +3 more
openaire   +2 more sources

Stacy Banwell (2023) The War Against Nonhuman Animals: A Non-Speciesist Understanding of Gendered Reproductive Violence. Cham: Palgrave Macmillan

open access: yesInternational Journal for Crime, Justice and Social Democracy
Stefano Porfido reviews The War Against Nonhuman Animals: A Non-Speciesist Understanding of Gendered Reproductive Violence by Stacy Banwell.
Stefano Porfido
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Were Neanderthals Rational? A Stoic Approach

open access: yesHumanities, 2018
This paper adopts the philosophical approach of Stoicism as the basis for re-examining the cognitive and ethical relationship between Homo sapiens and Neanderthals.
Kai Whiting   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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