Results 71 to 80 of about 684 (253)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Sokak Hayvanlarının Medyada Ötekileştirici Temsili Üzerine Bir Tematik Analiz

open access: yesİletişim Kuram ve Araştırma Dergisi
Türcülük, insan-merkezli bir hiyerarşi kurarak insan dışı canlılar olan hayvanları alt sınıflara yerleştiren, onları toplumsal, hukuki ve ahlaki açıdan değersizleştiren bir ötekileştirme biçimi olarak tanımlanmaktadır.
Çağla Daşcı
doaj   +1 more source

Gisele Kronhardt Scheffer (coord.). Direito animal e ciências criminais - Canal Ciências Criminais (Porto Alegre/RS/Brazil, 2018) 160 p.

open access: yesDerecho Animal, 2019
The book, coordinated by Gisele Kronhardt Scheffer, brings together fourteen chapters, written by different authors, dealing with various themes of Animal Law, with a multidisciplinary approach, especially focused on an ethical, legal and empirical ...
Vicente de Paula Ataide Junior
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

TAHAKKÜMÜN MUHAKEMESİ: İHVÂN-I SAFÂ’DA HAYVANLARIN ÖZGÜRLEŞME MÜCADELESİ

open access: yesİslami İlimler Dergisi
İslam düşüncesinde hayvan etiğiyle alakalı karşımıza çıkan en dikkat çekici metinlerden biri, İhvân-ı Safâ Risâleleri’nin “Hayvanların Yaratılışının Keyfiyeti ve Onların Sınıfları Üzerine” başlıklı yirmi ikinci risâlesidir.
Abdullah Özkan
doaj   +1 more source

Le World Wild Web et l’animalisme radical

open access: yesIm@go. A Journal of the Social Imaginary, 2016
After a first escalation on the nineteenth century, animal liberation phenomenon knows an hermeneutics rehabilitation through the web network development. Thanks to the virality of electronic channels, many people are being connected to animalism warfare
Marianne Celka
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Anti Robot Speciesism

open access: yesCoRR
Humanoid robots are a form of embodied artificial intelligence (AI) that looks and acts more and more like humans. Powered by generative AI and advances in robotics, humanoid robots can speak and interact with humans rather naturally but are still easily recognizable as robots.
Julian De Freitas   +3 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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