Results 81 to 90 of about 7,978 (300)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Relations, 2015 The idyllic view of nature is false: natural processes, given the prevalence of the reproductive strategy known as “r-selection”, tend to maximize the suffering of animals in nature. For the animals subjected to natural processes, disvalue overwhelmingly
Luciano Carlos Cunha
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Is it morally permissible to eat meat? [PDF]
Many approaches have been taken regarding this topic, some of them are anthropological or scientific that pursue the understanding of why we eat meat, but from the philosophical lens this question is solved in the field of applied ethics, which is the ...
Diez De Fex, Ana Maria
core
The Immorality of Eating Meat [PDF]
, 2000 Unlike other ethical arguments for veganism, the argument advanced is not predicated on the wrongness of speciesism, nor does it depend on your believing that all animals are equal or that all animals have a right to life, nor is it predicated on some ...
Engel, Mylan
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Imperatyw opieki paliatywnej w medycynie weterynaryjnej
Ethics in Progress, 2016 One of the main causes of the ethical ambivalence in the attitude of homo sapiens species towards other living creatures is its utilitarian and anthropocentric mindset which permeates practical decisions and judgments.
Krzysztof Kuśnierz
doaj +1 more source
Children and Pets: The Hidden Victims of Domestic Violence & Abuse (DVA): Where Action & Activism merge! [PDF]
, 2019 Children and Pets: The Hidden Victims of Domestic Violence & Abuse (DVA): Where Action & Activism merge! Researchers such as Harne (2011) and Radford et al (2011) have long championed the area of Children’s rights in the DVA field and the Government ...
McKie, Ruth, Turgoose, Di
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source