Results 121 to 130 of about 1,427,330 (251)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Quality Control of Stem Cell-Based Cultured Meat According to Specific Differentiation Abilities

Cells
The demand for stem cell-based cultured meat as an alternative protein source is increasing in response to global food scarcity. However, the definition of quality controls, including appropriate growth factors and cell characteristics, remains ...
Yuna Naraoka, Yo Mabuchi, Mai Kiuchi, Kyoko Kumagai, Daisuke Hisamatsu, Yosuke Yoneyama, Takanori Takebe, Chihiro Akazawa   +7 more
doaj   +1 more source

Using neurite orientation dispersion and density imaging and tracts constrained by underlying anatomy to differentiate between subjects along the Alzheimer's disease continuum [PDF]

, 2019
OBJECTIVE: To assess the involvement of the white matter of the brain in the pathology of Alzheimer’s disease. Using Neurite Orientation Density and Dispersion Imaging (NODDI) and the probabilistic white matter parcellation tool Tracula as a means for ...
Zhang, Zannan
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ranging the Results Achieved in Biomotoric and Specific-Motoric Skills in Handball Players and Non-Athletes Cadet [PDF]

Sport Mont, 2016
The goal of research is to establish differences in biomotoric space with young people at the age of cadets (14 ± 6 months; 15 ± 6 months) from Montenegro.
Aldijana Muratović, Danilo Bojanić
doaj  

Empathy and theory of mind abilities of children with specific learning disorder (SLD)

Psychiatry and Clinical Psychopharmacology, 2018
OBJECTIVES: Specific learning disorder (SLD) is a very common disorder in childhood, and it is discussed under neurodevelopmental disorders in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
Damla Eyuboglu, Nurullah Bolat, Murat Eyuboglu   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A TASMAN Expedition: Development of a Questionnaire to Assess Specific Self-Management Abilities

International Journal of COPD, 2020
M Voorhaar,1 J Tiemensma,2 GM Asijee,1 AHM Slok,1 JWM Muris,1 AA Kaptein3 1Department of Family Medicine, Maastricht University, CAPHRI Care and Public Health Research Institute, Maastricht, the Netherlands; 2Department of Anesthesiology, Erasmus ...
Voorhaar M, Tiemensma J, Asijee GM, Slok AHM, Muris JWM, Kaptein AA   +5 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

THE EFFECT OF TEACHER, PEER, AND SELF-EDITING ON IMPROVING GRAMMATICAL ACCURACY IN EFL LEARNERS’ WRITING [PDF]

Diversitate si Identitate Culturala in Europa, 2012
The aim of this study was to explore the effect of teacher, peer, and self-editing on the improvement of grammatical accuracy in writing, using three groups of participants.
Meysam HEMATI
doaj