Results 141 to 150 of about 2,089,298 (305)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Daya Gabung Dan Heterosis Karakter Vegetatif, Generatif, Dan Daya Hasil Jarak Pagar (Jatropha Curcas L.) Menggunakan Analisis Dialel [PDF]

, 2015
General Combining Ability (GCA) and Specific Combining Ability(SCA) are important in creating high yielding varieties. A parent havinghigh GCA is appropriate to produce synthetic or composite varieties, whilehigh SCA is to produce hybrid.
HARTATI, R. S. (RR), SUDARSONO, S. (SUDARSONO)   +1 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genetic analysis of grain yield and related traits of extra-early orange maize inbred lines and their hybrids under drought and rain-fed conditions

Frontiers in Plant Science
BackgroundOrange maize genotypes are sources of provitamin A (PVA) carotenoids, which are precursors of vitamin A. PVA deficiency and drought constitute major challenges causing increasing food and nutritional insecurity in sub-Saharan Africa (SSA ...
Tégawendé Odette Bonkoungou, Tégawendé Odette Bonkoungou, Baffour Badu-Apraku, Victor Olawale Adetimirin, Kiswendsida Romaric Nanema, Idris Ishola Adejumobi   +5 more
doaj   +1 more source

Introducing hierarquical hybrid logic [PDF]

, 2014
This paper introduces HHL, a hierarchical variant of hybrid logic. First-order correspondence and a Hennessy-Milner like theorem relating (hierarchical) bisimulation and logical equivalence for HHL are presented.
Barbosa, L. S., Madeira, Alexandre, Martins, Manuel A., Neves, Renato   +3 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Evaluation of combining ability and genetic analysis for salinity tolerance in a 7 × 7 F1 half-diallel population of groundnut (Arachis hypogaea L.)

Discover Plants
A study was conducted at the net house of Sher-e-Bangla Agricultural University in Dhaka to develop salt-tolerant and high-yielding groundnut genotypes.
Md. Akram Hossain Chowdhury, Md. Shahidur Rashid Bhuiyan, Md. Shah-E-Alam, Md. Sarowar Hossain, Md. Fazlul Karim, Shahanaz Parveen, Md. Harun-Ur-Rashid   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessment of combining ability for grain yield and its attributing traits in maize (Zea mays L.)

Discover Agriculture
A comprehensive understanding of combining ability is an emerging focus in hybrid maize research in Nepal. The present study aimed to evaluate the performance of single-cross maize hybrids and to estimate the combining abilities of parental lines for ...
Jiban Shrestha, Surya Kant Ghimire, Krishna Hari Dhakal, Mahendra Prasad Tripathi   +3 more
doaj   +1 more source