Results 161 to 170 of about 3,054,711 (370)

Genetic analysis of grain yield and related traits of extra-early orange maize inbred lines and their hybrids under drought and rain-fed conditions

open access: yesFrontiers in Plant Science
BackgroundOrange maize genotypes are sources of provitamin A (PVA) carotenoids, which are precursors of vitamin A. PVA deficiency and drought constitute major challenges causing increasing food and nutritional insecurity in sub-Saharan Africa (SSA ...
Tégawendé Odette Bonkoungou   +5 more
doaj   +1 more source

Introducing hierarquical hybrid logic [PDF]

open access: yes, 2014
This paper introduces HHL, a hierarchical variant of hybrid logic. First-order correspondence and a Hennessy-Milner like theorem relating (hierarchical) bisimulation and logical equivalence for HHL are presented.
Barbosa, L. S.   +3 more
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Combining abilities and heterotic groups in Pisum sativum L. [PDF]

open access: yes, 2013
The objective of this research was to investigate the use of heterosis and estimates of the general combining ability (GCA) and specific combining ability (SCA) for yield and the yield-related traits for identifying suitable parents and forming heterotic
Cointry Peix, Enrique Luis   +4 more
core  

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Estimation of heterosis and the ability to combine yield attributes and seed yield in Indian mustard (Brassica juncea)

open access: yesThe Indian Journal of Agricultural Sciences
The study was carried out during winter (rabi) season of 2021–22 and 2022–23 at ICAR-Indian Institute of Soybean Research, Indore, Madhya Pradesh to analyse Line × Tester to estimate the general combining ability (GCA) and specific combining ability ...
KUNWAR HARENDRA SINGH   +5 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

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