This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
The three-dimensional impulse-response model: Modeling the training process in accordance with energy system-specific adaptation. [PDF]
Kontro H +3 more
europepmc +1 more source
Machine learning-based estimation of structure-specific load around the ankle and knee joint during running using IMU data. [PDF]
Bogaert S, Davis J, Vanwanseele B.
europepmc +1 more source
The impact of intranasal oxytocin administration and social observation on time perception and task execution in a simple motor task. [PDF]
Kiss O +4 more
europepmc +1 more source
Test-Retest Reliability of Maximal and Rapid Knee Extensor Force Production: Influence of Verbal Instruction and Trial Selection Criteria. [PDF]
Sørensen AB, Mathiesen J, Aagaard P.
europepmc +1 more source
Eye Drift Signal Analysis Caused by Goggle Slippage in vHIT Measurements: A Signal Processing Perspective. [PDF]
Khoan HN, Bien LK, Nhan TT, Nghia TV.
europepmc +1 more source
Simulated gait training improves joint loading symmetry in unilateral transfemoral bone-anchored limb users. [PDF]
Vandenberg NW +5 more
europepmc +1 more source
Optimization of Variable-Specific-Impulse Interplanetary Trajectories
An indirect optimization method is used to find optimal trajectories that use solar electric propulsion. Missions that exploit variable specific impulse are compared to constant-specific-impulse trajectories, and the benefit, in terms of payload, is highlighted. The presence of limits on the attainable values of the specific impulse and the use of dual-
Lorenzo Casalino, COLASURDO, Guido
openaire +5 more sources
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