Results 51 to 60 of about 98,594 (308)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ground and flight tests of AlSat-1B butane propulsion system

Propulsion and Power Research, 2022
On September 26, 2016 Algerian Space Agency launched AlSat-1B, the second in a series of medium resolution earth observation satellites mission. AlSat-1B electro-thermal propulsion system follows the classic design principle that has been used on ...
D. Darfilal, D. Gibbon
doaj   +1 more source

A population-specific HTR2B stop codon predisposes to severe impulsivity [PDF]

Nature, 2010
Impulsivity, describing action without foresight, is an important feature of several psychiatric diseases, suicidality and violent behaviour. The complex origins of impulsivity hinder identification of the genes influencing it and the diseases with which it is associated.
Bevilacqua, Laura, Doly, Stéphane, Kaprio, Jaakko, Yuan, Qiaoping, Tikkanen, Roope, Paunio, Tiina, Zhou, Zhifeng, Wedenoja, Juho, Maroteaux, Luc, Diaz, Silvina, Belmer, Arnaud, Hodgkinson, Colin, Dell'Osso, Liliana, Suvisaari, Jaana, Coccaro, Emil, Rose, Richard, Peltonen, Leena, Virkkunen, Matti, Goldman, David   +18 more
openaire   +4 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Optimization of the Characteristics of High-Energy Materials

MATEC Web of Conferences, 2015
In work explored effect of mixed metallic fuel on the thermodynamic and ballistic characteristics of High-Energy Materials (HEMs). Efficiency of mixed metallic fuel estimated in relation to the characteristics of HEMs, containing conventional metallic ...
Kuznetsova Viktoriya, Savelieva Lilia
doaj   +1 more source

Effect of Combustion Chamber Geometrical Parameters on the Decomposition and Combustion Characteristics of an ADN-Based Thruster

Micromachines, 2022
In this paper, numerical simulations were used to study the decomposition and combustion processes inside the 0.2 N-class ADN-based thruster, and the effects of two geometrical parameters (length and diameter) of the combustion chamber on the combustion ...
Yangyang Hou, Yusong Yu, Xuhui Liu, Jie Cao   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Unique aspects of impulsive traits in substance use and overeating: specific contributions of common assessments of impulsivity [PDF]

The American Journal of Drug and Alcohol Abuse, 2014
Abstract Background: Impulsivity is a complex trait often studied in substance abuse and overeating disorders, but the exact nature of impulsivity traits and their contribution to these disorders are still debated. Thus, understanding how to measure impulsivity is essential for comprehending addictive behaviors.Identify unique impulsivity traits ...
Derek, Beaton, Hervé, Abdi, Francesca M, Filbey   +2 more
openaire   +2 more sources