Results 121 to 130 of about 2,290,362 (336)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Experiment and numerical investigation on bio-inspired tube-plate hybrid lattice structure with dual-stress plateaus and enhanced energy absorption

Virtual and Physical Prototyping
Lattice structures have drawn significant interest owing to their exceptional mechanical properties, e.g. lightweight, strong, and tough performance. Here, inspired by the biostructure of the beetle elytra, a new tube-plate hybrid lattice structure (TPHL)
Mingzhi Wang, Yinzhu Wang, Jianjun Wu, Weidong Wang   +3 more
doaj   +1 more source

Mechanical limits of viral capsids

, 2007
We study the elastic properties and mechanical stability of viral capsids under external force-loading with computer simulations. Our approach allows the implementation of specific geometries corresponding to specific phages such as $\phi$29 and CCMV. We
DiDonna, Dubois, Helgstrand, Klug, Kumar, M. Buenemann, Olson, P. Lenz, QUINTERO GARCIA, Riemer, Seung, Smith, Tao, Xiao   +13 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effect of specified edge load on Eucalyptus globulus paper properties [PDF]

, 2006
Refining is an important unit operation in the paper production process and consists in the mechanical beating of the pulp fibres in an aqueous medium. The refining conditions affect fibre morphology, pulp suspension characteristics and paper properties.
Anjos, O., Peralta, C., Piçarra, E., Santos, A., Simões, R.   +4 more
core  

Entropy-Preserving Coupling Conditions for One-dimensional Euler Systems at Junctions

, 2018
This paper is concerned with a set of novel coupling conditions for the $3\times 3$ one-dimensional Euler system with source terms at a junction of pipes with possibly different cross-sectional areas.
Lang, Jens, Mindt, Pascal
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Investigation on the microstructure and compressive behavior of open-cell copper- Al2O3 composite foams

Journal of Materials Research and Technology
The objective of this study is to evaluate the mechanical behavior and energy absorption characteristics of open-cell copper- Al2O3 composite foams fabricated using polyurethane foam with an average pore size of 1.2 mm and a combination of electroless ...
Fatemeh Besharati, Mohammad Hossein Paydar   +1 more
doaj   +1 more source